Tag: genetic factors

1. Lower RBFOX1 was associated with greater amyloid burden in the prefrontal cortex. 2. Reduced RBFOX1 was associated with increased rate of decline and reduced neurocognitive performance, and may be a novel locus for preclinical and early Alzheimer’s disease. Evidence Rating Level: 1 (Excellent) Study Rundown: Genome-wide association studies (GWAS) have identified greater...
1. Elevated FGF-23 concentration was associated with increased risk of adverse cardiovascular (CV) outcomes, including CV death and heart failure hospitalization. 2. Elevated FGF-23 was also associated with increased risk of all-cause mortality. Evidence Rating Level: 2 (Good) Study Rundown: Fibroblast growth factor 23 (FGF-23) is a protein hormone that inhibits renal...
1. Among individuals with high genetic risk for coronary artery disease (CAD), a favorable lifestyle was associated with a nearly 50% lower relative risk compared to an unfavorable lifestyle. 2. The relative risk of CAD was nearly doubled among participants with high genetic risk compared with participants at low genetic...
1. LDL-C-lowering alleles at the NPC1L1 locus are directly associated with an increased risk of type 2 diabetes, but a lower risk of coronary artery disease. 2. LDL-C lowering alleles at HMGCR and PCSK9 loci are similarly associated with coronary artery disease and type 2 diabetes. Evidence Rating Level: 1 (Excellent) Study...
1. Men with metastatic prostate cancer had a significantly higher incidence of germline mutations mediating DNA-repair processes compared to men with localized prostate cancer. 2. This study created the potential for earlier detection of germline mutations and targeted therapy earlier for men with metastatic prostate cancer. Evidence Rating Level: 2 (Good) Study...
1. This observational study found that BMI is associated with a genetic risk score calculated from multiple loci. 2. This association is present in both white and black cohorts, with the magnitude of the association strengthening in more recent birth cohorts. Evidence Rating Level: 2 (Good) Study Rundown: The obesity epidemic in...
Image: PD 1. Children of persistent smokers were much more likely to have smoked in the past year than children of non-smokers.  2. Adolescents who have an older sibling that smokes were much more likely to have also smoked in the past year. Evidence Rating Level: 1 (Excellent) Study Rundown: Adolescent smoking is...