Tag: hypoglycemia

1. Tirzepatide was superior to placebo with regard to changes in HbA1c, serum glucose, body weight loss, and proportion of patients achieving HbA1c targets of less than 7.0%. 2. Compared to placebo, the proportion of adverse events with tirzepatide were mildly elevated. Evidence Rating Level: 1 (Excellent) Study Rundown: In many patients...
1. Participants using the novel advanced hybrid insulin delivery system (Medtronic) had a greater proportion of time spent in their target glucose range versus control. 2. Proportion of time spent in hypoglycemic ranges was non-inferior between the Medtronic and control groups. Evidence Rating Level: 1 (Excellent) Study Rundown: Although various technological advances...
1. Participants using the novel advanced hybrid insulin delivery system (Medtronic) had a greater proportion of time spent in their target glucose range versus control. 2. Proportion of time spent in hypoglycemic ranges was non-inferior between the Medtronic and control groups. Evidence Rating Level: 1 (Excellent) Study Rundown: Although various technological advances...
1. In this randomized, double-blind, phase two trial, the use of golimumab led to more C-peptide production, indicative of improved endogenous function, compared to placebo in new type 1 diabetics. 2. Patients that received golimumab used less exogenous insulin compared to placebo. Evidence Rating Level: 2 (Good) Study Rundown: TNF-α has been...
1. In this large, longitudinal cohort study from the United States, patients with poor health status were more likely to continue insulin use compared with healthier patients. Evidence Rating Level: 2 (Good) Study Rundown: Type 2 Diabetes Mellitus (DM2) is one of the most common chronic illnesses in the world. Glycemic...
1. In this randomized controlled trial, intensive hyperglycemia treatment did not lead to improved outcomes compared to standard treatment in patients 90 days after stroke. 2. The intensive therapy group experienced more episodes of hypoglycemia and more adverse events attributed to hypoglycemia. Evidence Rating Level: 1 (Excellent) Study Rundown: Hyperglycemia is common in...
1. In this randomized controlled trial, intensive hyperglycemia treatment did not lead to improved outcomes compared to standard treatment in patients 90 days after stroke. 2. The intensive therapy group experienced more episodes of hypoglycemia and more adverse events attributed to hypoglycemia. Evidence Rating Level: 1 (Excellent) Study Rundown: Hyperglycemia is common...
1. There was no difference in cardiovascular or all-cause mortality between any of the various glucose-lowering agent combinations 2. Each drug combination had a different profile with regards to body weight, risk of hypoglycemia, and risk of treatment failure, indicating that diabetic regimens should be personalized. Evidence Rating Level: 1 (Excellent) Study...
1. When compared to codeine use, tramadol was associated with an increased risk of hospitalization for hypoglycemia in patients with non-cancer pain. 2. The highest risk of hospitalization occurred within the first 30 days of tramadol initiation. Evidence Rating Level: 3 (Average) Study Rundown: Use of the weak opioid tramadol...
Originally published by Harvard Health. What Is It? Hypoglycemia is an abnormally low level of blood sugar (blood glucose). Because the brain depends on blood sugar as its primary source of energy, hypoglycemia interferes with the brain's ability to function properly. This can cause dizziness, headache, blurred vision, difficulty concentrating and...