Tag: ischemic stroke

There are large differences in the incidence of stroke among various ethnic groups, as well as between sexes. These differences also vary significantly with age. In this prospective cohort study, 25,789 patients age 45 years and older who were stroke-free from the Reasons for Geographic and Racial Differences in...
Pegbelfermin (BMS-986036), a PEGylated Fibroblast Growth Factor 21 Analogue, in Patients with Non-Alcoholic Steatohepatitis: A Randomised, Double-Blind, Placebo-Controlled, Phase 2a Trial Non-alcoholic steatohepatitis (NASH), the most common chronic liver disease in the United States, puts patients at increased risk of developing cirrhosis and hepatocellular carcinoma. Patients with NASH are also...
1. In this randomized trial of patients with aphasia, use of anodal transcranial direct current stimulation (A-tDCS) demonstrated improved object naming compared to sham procedure. 2. Further study in the use of A-tDCS for aphasia recovery post-stroke may be warranted. Evidence Rating Level: 2 (Good)           Study Rundown: Aphasia remains a significant source...
1. In this cross-sectional study, young adults with a greater number of modifiable cardiovascular (CV) risk factors at recommended levels was associated with higher cerebral vessel density and caliber and higher cerebral blood flow. 2. Greater optimization of these CV risk factors were also associated with decreased white matter hyperintensities. Evidence...
1. In this randomized controlled trial, administration of alteplase within 3 hours of mild stoke did not lead to a reduction in disability at 90 days post-stroke compared to aspirin. 2. Patients treated with alteplase had a slightly higher rate of spontaneous intracranial hemorrhage but no differencesin mortality compared to...
1. In this cluster-randomized clinical trial, quality improvement interventions led to slightly greater adherence of evidence-based, performance measures compared to care as usual for acute ischemic stroke management in China. 2. Quality improvement interventions were associated with fewer vascular events and less stroke disability over one year of follow up. Evidence...
1. At a median follow-up of eleven months, rivaroxaban was not superior to aspirin for prevention of secondary stroke after an initial primary embolic stroke of undetermined source. 2. Use of rivaroxaban was associated with a higher rate of major bleeding relative to aspirin. Evidence Rating Level: 1 (Excellent) Study Rundown: Improvements...
1. Stroke patients with unknown time of stroke onset and DWI-FLAIR mismatch indicative of a stroke within the prior 4.5 hours who were randomized to alteplase were more likely to have a favorable outcome at 90 days than those receiving placebo. 2. Rates of death and symptomatic intracranial hemorrhage were...
1. When treated with tenecteplase, stroke patients eligible for mechanical thrombectomy had higher rates of reperfusion and superior clinical outcomes at 90 days relative to patients treated with alteplase. 2. There was no evidence that rates of intracerebral hemorrhage were different between the tenecteplase and alteplase groups. Evidence Rating Level: 1...
1. In this meta-analysis of prospective population-based studies, sickle cell trait (SCT) was not associated with any difference in risk of first ischemic stroke. 2. After adjusting for known ischemic stroke risk factors, the presence of SCT was still not linked to any different risk of ischemic stroke. Evidence Rating Level:...