Tag: opiods

1. In this randomized controlled trial, ibuprofen plus paracetamol significantly reduced morphine consumption in post-operative patients who underwent a total hip arthroplasty compared with paracetamol alone 2. There was no significant difference in serious adverse events in groups receiving ibuprofen and those receiving paracetamol. Evidence Rating Level: 1 (Excellent) Study Rundown: Multimodal...

1. Mu opioid peptide (MOP) receptor agonists provide effective pain relief, but are associated with severe side effects such as respiratory depression, opioid-induced hyperalgesia, dependence, and abuse. 2. A bifunctional nociception/ophanin FQ peptide (NOP) and MOP agonist, AT-121, partially acts at both receptors to provide analgesic effects without inducing common...

1. Children with a history of neonatal abstinence syndrome (NAS) had higher odds of qualifying for and receiving therapies and services for educational disabilities compared to similar peers without a history of NAS. 2. Classroom therapies or services for developmental delay and speech or language impairment were significantly more common...

1. Patients coprescribed opioids and pregabalin had significantly increased odds of opioid-related death compared to opioid prescription alone. 2. More than half of Ontario residents who take pregabalin are already prescribed opioids. Evidence Rating Level: 2 (Good) Study Rundown: Pregabalin is an anticonvulsant that is increasingly prescribed as an adjunct for chronic...