Tag: preterm infants

Little is known about the survival and neurodevelopmental outcomes of extremely preterm infants with low birth weight. More data is needed to facilitate decisions regarding the initiation of treatment and resuscitation in this population. In this retrospective cohort study, 205 infants born between 22 and 26 weeks gestational age...
1. In a meta-analysis of randomized studies evaluating efforts to reduce re-intubations and respiratory failure in preterm infants, non-invasive respiratory support and use of methylxanthines (theophylline, caffeine) were found to be beneficial. 2. Chest physiotherapy was also associated with lower risk extubation failure, but had adverse effects. Doxapram and corticosteroids...
1. Compared to term infants, preterm infants had lower anti-pneumococcal IgG concentrations after administration of the 13-valent pneumococcal conjugate vaccine (PCV13). However, the majority of both groups achieved a titer level above that recommended for adequate protection. 2. Opsonophagocytic activity of the antibodies in both term and preterm infants was...
1. Girls born before 34 weeks gestation were found to have higher blood pressures at age 16 than those born after 37 weeks. Boys born preterm had worse cholesterol levels in adolescence when compared to males born at term. 2. A dose-response relationship was observed with gestational age and health...
1. The administration of high dose recombinant erythropoietin to premature infants within 42 hours after birth was associated with a decreased risk of brain injury. 2. Analysis of the primary outcome of this study assessing brain development at 2 years of age is pending.             ...
1. Infants less than 27 weeks gestation born at high volume centers had lower neonatal mortality and lower any in-hospital mortality, regardless of center’s tertiary level status.  2.  Despite reorganization of perinatal centers in England, volume of care provided at center remains an important determinant of premature neonatal outcomes.  Evidence Rating...
Image: PD  1. The use of high-flow nasal cannulae was noninferior to the use of nasal CPAP according to a pre-specified margin of noninferiority.  2. The incidence of nasal trauma was significantly lower in the nasal-cannulae group than in the CPAP group.  Evidence Rating Level: 1 (Excellent)  Study Rundown: In this multicenter, randomized,...
Image: PD. RSV. 1. Prophylaxis with an anti-respiratory syncytial virus (RSV) monoclonal antibody significantly reduced wheezing and recurrent wheezing among preterm infants.  2. The reduction in wheezing occurred regardless of family history of atopy.  Evidence Rating Level: 1 (Excellent)  Study Rundown: The MAKI trial found that prophylaxis of pre-term infants with the anti-RSV monoclonal...
Image: PD/CDC 1. Extremely preterm infants assigned to a lower target oxygenation range of 85% to 89%, compared to 91% to 95%, showed no increased death or disability at 18 months.  2. Extremely premature infants in the lower target oxygenation cohort also did not have increased retinopathy of prematurity or brain...