Tag: SARS-CoV-2

1. Incidence of PCR-confirmed symptomatic COVID-19 cases was lower in the vaccine group compared with the placebo group (p<0.0001). 2. The majority of adverse events were mild and there was no vaccine-related mortality.  Evidence Rating Level: 1 (Excellent) Study Rundown: Inactivated vaccines offer a variety of benefits against transmission of severe acute...
1. Among patients hospitalized with severe COVID-19 and hyperinflammation, treatment using the anti-interleukin-1β antibody canakinumab, compared with placebo, did not significantly increase the likelihood of survival without invasive mechanical ventilation at day 29. 2. These findings for canakinumab vs placebo were also consistent for the secondary outcome of COVID-19-related mortality...
1. Health care assistants and nurses were at the highest risk of contracting SARS-CoV-2 among healthcare professionals early in the COVID-19 pandemic in Italy. 2. Healthcare workers employed in operational units that may result in prolonged exposure to SARS-CoV-2 patients, such as internal medicine and related subspecialties, were at higher...
1. Very high risk individuals that qualified for shielding interventions from COVID-19 were still at elevated risk for developing a severe infection. 2. Recent hospital exposures were the greatest risk factor for developing a case of severe COVID-19, among patients eligible for shielding interventions. Evidence Rating Level: 3 (Average) Towards the beginning...
1. The incidence of chilblains increased during the COVID-19 pandemic, but chilblains cases were only weakly associated with COVID-19 infection, with only 2.0% of patients testing positive for COVID-19. Evidence Rating Level: 2 (Good) Chilblains refer to lesions of the skin related to inflammation from cold, damp conditions. During the start...
1. Most people who died with COVID-19 showed myositis of various severities. 2. Patients who died with COVID-19 had greater overall pathology and inflammation than those who died without COVID-19. Evidence Rating Level: 2 (Good) Study Rundown: Myalgia is commonly reported among those infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),...
1. Retrospective analysis of hospital records showed decreased hospital admission rates for non-COVID-19 diseases in Denmark since the first lockdown. 2. Mortality rates were also shown to be higher for non-COVID-19 diseases, including respiratory diseases, cancer, pneumonia, and sepsis. Evidence Rating Level: 2 (Good) Study Rundown: The COVID-19 pandemic has put a...
1. Therapeutic anticoagulation with rivaroxaban or enoxaparin did not improve clinical outcomes and increased bleeding compared with prophylactic anticoagulation. 2. Net clinical benefit composite of death, thrombotic events, and major or clinically relevant non-major bleeding was not significantly different between groups. Evidence Rating Level: 1 (Excellent) Study Rundown: COVID-19 is associated with...
1. In this epidemiological cohort study based out of Valencia, Spain, the neighborhood where the hospital and COVID-19 testing facility was situated correlated with a high number of total infectious connections and was potentially a major contributor to local spread. 2. These findings suggest that a more selective and strategic...
1. Clinical visits for postpartum mental health illness increased in the first 9 months of the COVID-19 pandemic comparatively to pre-pandemic rates, peaking between 0 and 90 days after birth.  2. In Ontario, Canada, postpartum people living in low income neighbourhoods had less significant visit increases compared to higher income...