Tag: SSRI

1. Selective serotonin reuptake inhibitor use among children and adolescents with public health insurance was found to be associated with a mildly increased risk for the developed of type 2 diabetes mellitus. 2. The magnitude of this risk, overall, was substantially lower than that of other risk factors for the...

1. Selective serotonin reuptake inhibitor use among children and adolescents with public health insurance was found to be associated with a mildly increased risk for the developed of type 2 diabetes mellitus. 2. The magnitude of this risk, overall, was substantially lower than that of other risk factors for the...

1. Many first-line agents for depression and anxiety – including specific SSRIs, bupropion, and especially venlafaxine – were associated with an increased risk of birth defects if used during early pregnancy. Evidence Level Rating: 2 (Good) The management of depression and anxiety during pregnancy is challenging, especially considering that they affect...

1. Selective serotonin reuptake inhibitors (SSRIs) are not associated with significant short-term reductions in depressive symptoms in the primary care setting, but reduce short-term anxiety and improve mental health and health-related quality of life. Evidence Rating Level: 1 (Excellent) While most patients with depression are managed in the primary care setting,...

The clinical effectiveness of sertraline in primary care and the role of depression severity and duration (PANDA): a pragmatic, double-blind, placebo-controlled randomised trial 1. Selective serotonin reuptake inhibitors (SSRIs) are not associated with significant short-term reductions in depressive symptoms in the primary care setting, but reduce short-term anxiety and improve...

A meta-analysis of 18 studies examining the association of prenatal antidepressant exposure with motor development in children showed a small overall effect of worse motor development outcomes among children exposed to antidepressants in pregnancy. Evidence Rating Level: 1 (Excellent) Study Rundown: Antidepressants are among the most commonly prescribed medications in the...

1. Neonatal intensive care unit (NICU) admittance was higher among infants born to women receiving selective serotonin reuptake inhibitors (SSRIs) during pregnancy compared to nonexposed infants. 2. Maternal SSRI use during late pregnancy was associated with an increase in infant respiratory and CNS-related disorders, hypoglycemia, and feeding difficulties compared to...

1. In this retrospective cohort study of Danish mothers and children, maternal use of newer antidepressants (e.g. SSRIs, nefazodone, mirtazapine, venlafaxine, and roboxetine) during pregnancy was not associated with an increased risk of childhood asthma. 2. Maternal prenatal use of older antidepressants (e.g. tricyclic antidepressants) was associated with an approximately...

Image: PD 1. Mothers’ prenatal selective serotonin reuptake inhibitor (SSRI) use was linked to an increased risk of autism spectrum disorder (ASD) in male children. 2. The risk of ASD was highest among those mothers who used SSRIs in the first trimester.  Evidence Rating Level: 3 (Average) Study Rundown: SSRIs can cross the...

Image: PD In this section, we will highlight the key high-impact studies, updates, and analyses published in medicine during the past week. Three vs Twelve Months of Dual Antiplatelet Therapy After Zotarolimus-Eluting Stents: The OPTIMIZE Trial Studies ascertaining the optimal length of antiplatelet therapy after placement of drug-eluting stents have provided mixed...