Tag: statins

1. Continuation of statins after an adverse event is associated with reduced risk of cardiovascular events (stroke or myocardial infarction) and death. 2. Study results may assist patients and their doctors in weighing the benefits and risks of statin therapy and help them to select a treatment plan that is...
1. In this propensity-matched retrospective cohort study, perioperative statin use was associated with reduced risk of 30-day mortality and risk of postoperative complications. 2. Sub-analyses indicated that patients with pre-existing ischemic heart disease, diabetes, age <75 years old, high risk surgery and use of high-intensity statin therapy may have the...
1. In a retrospective cohort analysis, statin medications were strongly associated with acute memory impairment when compared to patients not on any lipid lowering drugs (LLDs). This was most pronounced in the first 30 and 60 days, but the positive relationship remained in the long term as well. Very...
1. A computer simulation shows that the use of statins for primary prevention in those older than 75 years of age may reduce coronary heart disease-related morbidity and mortality. 2. The net cost benefit of all primary prevention strategies in the elderly were highly dependent on the assumptions made regarding...
In this section, we highlight the key high-impact studies, updates, and analyses published in medicine during the past week. Effect of a Postdischarge Virtual Ward on Readmission or Death for High-Risk Patients With the recent changes in reimbursement in America penalizing hospitals that have high readmission rates, there is now an...
1. In this observational trial, generic statins were associated with better adherence rates and clinical outcomes compared to brand-name statins. Evidence Rating Level: 2 (Good) Study Rundown: Statins are one of the most commonly prescribed medications in the United States. However, it remains unclear how brand-name statins may differ...
1. Statin use following diagnosis of colorectal cancer was associated with dose-dependent reductions in cancer-specific and all-cause mortality.            Evidence Rating Level: 2 (Good)  Study Rundown: Though primarily used in the management of hyperlipidemia and coronary heart disease, preclinical evidence has suggested that statins may play a...
1. Statin users had lower baseline Physical Activity Scale for the Elderly (PASE) scores, and the decline in points per year on the PASE scale was not statistically significant between statin users and non-users. 2. For new statin users, PASE scores declined at a faster rate than for non-users.  Accelerometer data...
Image: PD In this section, we highlight the key high-impact studies, updates, and analyses published in medicine during the past week. Pharmacotherapy for Adults With Alcohol Use Disorders in Outpatient Settings Despite continued high rates of morbidity and early mortality caused by alcohol use disorders (AUDs), less than 10% of patients with...
Image: PD  1. When paired with statin therapy, evolocumab greatly reduced patient low-density lipoprotein cholesterol (LDL-C) levels compared to placebo or ezetimibe.  2. Evolocumab paired with statin therapy reduced LDL-C levels in patients independent of statin type or treatment intensity across the three most common statins.  Evidence Rating Level: 1 (Excellent)  ...