• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Cardiology

Generic statins associated with better adherence and outcomes vs. brand names

bySai FolmsbeeandAimme Li, MD
September 15, 2014
in Cardiology, Chronic Disease
Reading Time: 3 mins read
0
Share on FacebookShare on Twitter

1. In this observational trial, generic statins were associated with better adherence rates and clinical outcomes compared to brand-name statins.

Evidence Rating Level: 2 (Good)

Study Rundown: Statins are one of the most commonly prescribed medications in the United States. However, it remains unclear how brand-name statins may differ from generic statins in clinical practice. This observational study found that those who took generic statins, when compared to brand-name statins, showed a greater adherence to the therapy. Furthermore, those on generic statins were associated with a small, but statistically significant, decrease in the risk of hospitalization for acute coronary syndrome (ACS). The greatest strength of this trial is its inclusion of over 90,000 patients. A major limitation was the potentially confounding effects in the different populations that took brand-name statins versus generic statins. For example, patients that took brand-name statins were more likely to be white, male, and have a higher income. Overall, this study suggests that brand-name statins are not superior to generic statins, and may be associated with worse adherence rates and clinical outcomes.

Click to read the study, published today in the Annals of Internal Medicine

Relevant Reading: Adherence to Lipid-lowering Therapy and the Use of Preventive Health Services: An Investigation of the Healthy User Effect

In-Depth [systematic review]: Among the 90,111 patients included in this study, 93% initiated a generic statin and 7% initiated a brand-name statin. Simvastatin was the most commonly prescribed statin. To assess adherence, the proportion of days covered (PDC) of each group was measured. A statistically significant difference in PDC was noted between the two groups: 77% in the generic group and 71% for the brand-name group. Hospitalization for ACS was the only outcome found to be significantly decreased in the generic group, with a matched hazard ratio of 0.92 [CI=0.85-0.99]. Additionally, the composite endpoint, which included cardiovascular events and death, was also found to be significantly lower in the generic group with an absolute decrease of 1.53 events per 100-person-years. Although this observational study is limited by possible confounding factors, the correlation between PDC and outcomes illustrates the potential importance of improving patient adherence to prevent cardiovascular events.

More from this author: Efavirenz (Sustiva) for HIV patients may increase risk of suicideSocial integration may reduce suicide risk in male health professionals Hormone therapy may not prevent atherosclerosis in menopausal womenElevated troponin in chronic kidney disease associated with increased mortalityLow-carb, not low-fat, diet linked with increased weight loss

RELATED REPORTS

Risk of myopathy and myalgia among statin users may be small and clinically insignificant

Polypill strategy reduces the risk of cardiovascular events after a myocardial infarction

Moderate-intensity statin plus ezetimibe is non-inferior to high-intensity statin monotherapy

Image: PD

©2012-2014 2minutemedicine.com. All rights reserved. No works may be reproduced without expressed written consent from 2minutemedicine.com. Disclaimer: We present factual information directly from peer reviewed medical journals. No post should be construed as medical advice and is not intended as such by the authors, editors, staff or by 2minutemedicine.com. PLEASE SEE A HEALTHCARE PROVIDER IN YOUR AREA IF YOU SEEK MEDICAL ADVICE OF ANY SORT.

Tags: Atorvastatinsimvastatinstatins
Previous Post

ACP recommends non-pharmacologic treatment of urinary incontinence in women

Next Post

Unexpected delivery outcomes associated with postpartum depression

RelatedReports

Gender conformity influences use of laxatives and muscle-building products
Cardiology

Risk of myopathy and myalgia among statin users may be small and clinically insignificant

September 20, 2022
Nearly Half of All Pediatric Buprenorphine Exposures Result in Hospitalization
Cardiology

Polypill strategy reduces the risk of cardiovascular events after a myocardial infarction

September 15, 2022
2 Minute Medicine Rewind October 12 – 19, 2014
Cardiology

Moderate-intensity statin plus ezetimibe is non-inferior to high-intensity statin monotherapy

August 10, 2022
Implementation of pneumococcal vaccine programs linked to decreased antibiotic prescription
Cardiology

Systematic review and meta-analysis of statin-induced reduction in LDL-C demonstrates modest absolute benefits

April 7, 2022
Next Post
High dose antidepressants may increase self-harm risk among children, young adults

Unexpected delivery outcomes associated with postpartum depression

Gender mismatch linked with autoimmune disease in chronic graft-vs-host disease

Gender mismatch linked with autoimmune disease in chronic graft-vs-host disease

Thoracic radiotherapy improves survival in small-cell lung cancer patients

Thoracic radiotherapy improves survival in small-cell lung cancer patients

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Metformin use may decrease risk of osteoarthritis development
  • Intensive blood pressure lowering by non-physician healthcare providers significantly reduces the risk of cardiovascular disease
  • Expectant management of patent ductus arteriosus noninferior to early ibuprofen use
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

Want more physician-written
medical news?

Join over 10 million yearly readers and numerous companies. For healthcare professionals
and the public.

Subscribe for free today!

Subscription options