Tag: simvastatin

The risk of adverse cardiovascular outcomes in patients hospitalized with acute coronary syndrome (ACS) is highest in elderly patients. Although recent clinical trials have shown that high-intensity statin therapy significantly reduces adverse cardiovascular events for patients with established coronary heart disease, its use in elderly individuals remains controversial. As...
Association of Immune Marker Changes With Progression of Monoclonal Gammopathy of Undetermined Significance to Multiple Myeloma Multiple myeloma often develops from the precursor condition monoclonal gammopathy of undetermined significance (MGUS), which is detectable in peripheral blood. Similarly, the light-chain subtype of multiple myeloma is preceded by light-chain MGUS. Clinical guidelines...
1. This study showed that the net benefit of statins compared to risk varied considerably with respect to the age of the patient, patient sex and the type of statin utilized. 2. This modeling study suggested that statins may be overprescribed even among at-risk patients. Evidence Rating Level: 3 (average) Study Rundown:...
Frozen vs fresh fecal microbiota transplantation and clinical resolution of diarrhea in patients with recurrent Clostridium difficile infection: A randomized clinical trial Clostridium difficile infection (CDI) has become a major burden in healthcare and community settings, with limited treatment options available for patients with recurrent, refractory infections. Recently, fecal microbiota...
1. Leiomyoma cells treated with simvastatin exhibited increased apoptotic activity and decreased proliferative activity. 2. Mice treated with simvastatin had decreased leiomyoma growth and decreased proliferative tumor activity. Evidence Rating Level: 2 (Good)   Study Rundown: Uterine fibroids, or leoiomyomas, are benign tumors found in women of reproductive age. While some women...
1. When compared with placebo, simvastatin did not significantly reduce the number of ventilator-free days in patients presenting with acute respiratory distress syndrome. 2. Moreover, simvastatin did not significantly reduce 28-day mortality as compared with placebo. Evidence Rating Level: 1 (Excellent) Study Rundown: Acute respiratory distress syndrome (ARDS) refers to a spectrum...
1. In this observational trial, generic statins were associated with better adherence rates and clinical outcomes compared to brand-name statins. Evidence Rating Level: 2 (Good) Study Rundown: Statins are one of the most commonly prescribed medications in the United States. However, it remains unclear how brand-name statins may differ...
Classics Series, Landmark Trials in Medicine
1. In patients with familial hypercholesterolemia, simvastatin and ezetimibe combination therapy does not result in significant differences in carotid artery thickness when compared to treatment with simvastatin alone. 2. Treatment with simvastatin and ezetimibe led to significantly greater reductions in LDL cholesterol, triglyceride, and C-reactive protein levels as compared to...
Image: PD  1. High dose simvastatin therapy reduced the annual brain atrophy rate over two years compared to placebo in patients with secondary progressive multiple sclerosis (MS).  2. Simvastatin was associated with a small but significant reduction in MS disability scores compared to placebo.  Evidence Rating Level: 1 (Excellent)  Study Rundown: Multiple sclerosis...