Tag: Atorvastatin

1. In this randomized, controlled trial, patients without cardiovascular disease randomized to receive a polypill containing atorvastatin, amlodipine, losartan, and hydrochlorothiazide experienced greater reductions in systolic blood pressure and low-density lipoprotein (LDL) cholesterol over 12 months compared to patients who received usual-care. 2. Polypill patients reported increased rates of myalgia,...
1. In this randomized, controlled trial, patients without cardiovascular disease randomized to receive a polypill containing atorvastatin, amlodipine, losartan, and hydrochlorothiazide experienced greater reductions in systolic blood pressure and low-density lipoprotein (LDL) cholesterol over 12 months compared to patients who received usual-care. 2. Polypill patients reported increased rates of myalgia,...
1. This study showed that the net benefit of statins compared to risk varied considerably with respect to the age of the patient, patient sex and the type of statin utilized. 2. This modeling study suggested that statins may be overprescribed even among at-risk patients. Evidence Rating Level: 3 (average) Study Rundown:...
  Randomized trial of labor induction in women 35 years of age or older Over the last 30 years, women in industrialized nations have been increasingly delaying childbirth. This has important implications in the obstetric management of these patients as the risk of perinatal death, gestational diabetes mellitus, placenta previa and...
1. In this observational trial, generic statins were associated with better adherence rates and clinical outcomes compared to brand-name statins. Evidence Rating Level: 2 (Good) Study Rundown: Statins are one of the most commonly prescribed medications in the United States. However, it remains unclear how brand-name statins may differ...
1. Statin use following diagnosis of colorectal cancer was associated with dose-dependent reductions in cancer-specific and all-cause mortality.            Evidence Rating Level: 2 (Good)  Study Rundown: Though primarily used in the management of hyperlipidemia and coronary heart disease, preclinical evidence has suggested that statins may play a...
Image: PD 1. Atorvastatin administration for both healthy donors and recipients of matched sibling allogeneic hematopoietic cell transplantation (HCT) represents feasible and safe potential acute GVHD prophylaxis. 2. Further investigation is needed to determine the effectiveness of this strategy. Evidence rating level: 2 (Good)  Study Rundown: Acute graft-versus-host disease (GVHD) causes significant morbidity...
Classics Series, Landmark Trials in Medicine
Image: CC/L. academia 1. In patients with recent stroke or TIA, high-dose atorvastatin significantly reduces the risk of fatal stroke compared to placebo 2. Atorvastatin was also associated with a significant reduction in risk of cardiovascular events Original Date of Publication: August 10, 2006 Study Rundown: While the trial demonstrated that atorvastatin after stroke...