• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • 2MM Podcast
  • Write for us
  • Contact Us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Cardiology

Polypill strategy reduces the risk of cardiovascular events after a myocardial infarction

byDavid XiangandKiera Liblik
September 15, 2022
in Cardiology, Chronic Disease
Reading Time: 3 mins read
0
Share on FacebookShare on Twitter

1. A polypill consisting of aspirin, ramipril, and atorvastatin reduced the risk of major adverse cardiovascular events after a myocardial infarction (MI). 

2. Medication adherence was higher in patients receiving the polypill compared to usual care.

Evidence Rating Level: 1 (Excellent)

Study Rundown: The incidence of recurrent ischemic events is increasing globally despite effective pharmacotherapies which have been developed for secondary prevention. Notably, patient adherence to secondary prevention medications is only estimated to be approximately 50%. It follows that a lack of adherence to these pharmaceuticals is associated with poor outcomes. A polypill strategy has been proposed to improve medication adherence through treatment simplification by reducing the number of medications taken. However, there is a gap in knowledge as to understanding the efficacy of a polypill-based strategy compared to usual care concerning major cardiovascular outcomes in older patients with recent myocardial infarction (MI). Overall, this study found that the polypill treatment strategy led to a lower frequency of cardiovascular events than a usual care strategy. This study was limited as no adjustment was made for multiple comparisons of secondary outcomes, and loss to follow-up may potentially bias comparisons between groups. Finally, the coronavirus disease 2019 pandemic might have precluded some patients from completing trial visits. Nevertheless, these study’s findings are significant, as they demonstrate that this polypill strategy can significantly reduce the risk of adverse cardiovascular events after a MI and can improve accessibility and adherence to treatment.

Click to read the study in NEJM

Relevant Reading: Cardiac Rehabilitation and Secondary Prevention of Coronary Heart Disease

RELATED REPORTS

#VisualAbstract: Routine Cerebral Embolic Protection Did Not Reduce Stroke Incidence during Transcatheter Aortic-Valve Implantation

The Scan by 2 Minute Medicine®: Celebrity diagnoses spur screenings, athlete mental-health push, reality-TV heart lesson, and a sitcom PSA wave

2 Minute Medicine Rewind June 30, 2025

In-Depth [randomized controlled trial]: The present phase three randomized control trial was conducted at 113 centers across Europe. In this trial, patients with a MI within the previous six months were assigned to a polypill strategy or usual care. The polypill regimen consisted of aspirin, ramipril, and atorvastatin. Patients with a history of type one MI within the previous 6 months and who were older than 75 or 65 with a risk factor such as diabetes or kidney disease were eligible for the study. Patients who were receiving oral anticoagulation were excluded from the study. The primary outcome measures were cardiovascular death, nonfatal type one MI, nonfatal ischemic stroke, and urgent revascularization. Outcomes in the primary analysis were assessed via noninferiority according to the intention to treat principle with Kaplan-Meier analyses and log-rank tests. Based on the primary analysis, a primary outcome event occurred in 9.5% of patients in the polypill group and in 12.7% of patients in the usual care control group (Hazard Ratio [HR] 0.76; 95% Confidence Interval [CI] 0.6 to 0.96). A key secondary outcome event occurred in 8.2% of the polypill group and in 11.7% of the usual care group (HR 0.7; 95% CI 0.54 to 0.9). Medication adherence at six months as reported by patients was higher in the polypill group at 70.6% compared to 62.7% in the usual care group (Risk Ratio 1.13; 95% CI 1.06 to 1.2). In summary, this study demonstrates that a polypill treatment strategy significantly reduces the risk of major cardiovascular adverse events after a MI in older patients and significantly improves adherence to these key medications.

Image: PD

©2022 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: acute coronary syndromeacute myocardial infarctionaspirinAtorvastatincardiologycardiovascular eventschronic diseasemyocardial infarctionpharmacologypolypillramipril
Previous Post

Human papillomavirus infection is associated with adenocarcinoma of the cervix [Classics Series]

Next Post

Wellness Check: Sleep

RelatedReports

#VisualAbstract: Routine Cerebral Embolic Protection Did Not Reduce Stroke Incidence during Transcatheter Aortic-Valve Implantation
All Specialties

#VisualAbstract: Routine Cerebral Embolic Protection Did Not Reduce Stroke Incidence during Transcatheter Aortic-Valve Implantation

July 3, 2025
The Scan by 2 Minute Medicine®:  Ultra-Trail du Mont-Blanc, Taylor Swift, NBA rookie Chet Holmgren and Magic Mushrooms!
The Scan by 2 Minute Medicine®

The Scan by 2 Minute Medicine®: Celebrity diagnoses spur screenings, athlete mental-health push, reality-TV heart lesson, and a sitcom PSA wave

July 2, 2025
Quick Take: Functional Outcome of Intravenous Thrombolysis in Patients With Lacunar Infarcts in the WAKE-UP Trial
Weekly Rewinds

2 Minute Medicine Rewind June 30, 2025

June 30, 2025
Chronic Disease

Weighted vests and resistance training confer similar outcomes for bone density in the elderly

June 27, 2025
Next Post
Sleep duration, sleepiness, chronotype have variable associations with teen self-regulation

Wellness Check: Sleep

Patient transfers to trauma centers often unnecessary

Enteral glutamine does not reduce the time to discharge for severe burns

The ABCD2 score: Risk of stroke after Transient Ischemic Attack (TIA) [Classics Series]

Intraperitoneal chemotherapy improves advanced ovarian cancer survival [Classics Series]

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Artificial intelligence based clinical decision systems are safe and effective for diabetes management
  • Epic Launchpad propels generative-AI into everyday hospital routines
  • #VisualAbstract: Routine Cerebral Embolic Protection Did Not Reduce Stroke Incidence during Transcatheter Aortic-Valve Implantation
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
No Result
View All Result

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.