Tag: thrombocytopenia

1. Preterm infants given prophylactic platelet transfusions at thresholds below 50,000 platelets per cubic millimeter had higher risks of death or major bleeding after 28 days as compared to neonates given transfusions at thresholds below 25,000 per cubic millimeter. 2. There was no significant difference in other serious adverse events...
1. For preterm infants with echocardiographically-confirmed patent ductus arteriosus (PDA) within the first 14 days of life, there was no significant difference in the timing of PDA closure between infants who received liberal versus restrictive platelet transfusions. 2. Infants in the liberal transfusion group had significantly higher rates of intraventricular...
1. Preterm infants given prophylactic platelet transfusions at thresholds below 50,000 platelets per cubic millimeter had higher risks of death or major bleeding after 28 days as compared to neonates given transfusions at thresholds below 25,000 per cubic millimeter. 2. There was no significant difference in other serious adverse events...
1. Retrospective analyses demonstrated evidence of mean platelet count decline during pregnancy beginning as early as the first gestational trimester 2. Platelet counts were significantly lower among patients with documented pregnancy-related complications as compared to women with uncomplicated pregnancies. Evidence Rating Level: 2 (Good) Study Rundown: Gestational thrombocytopenia is defined by an...
1. In a review of children who presented to a specialist hematology clinic with isolated mild or moderate low platelet counts, though causes were variable, most required no interventions. 2. Pediatric patients with isolated mild or moderate thrombocytopenia may not need specialist referral to hematology in most circumstances. Evidence Rating Level:...
1. Imetelstat induced hematologic responses in 100% of essential thrombocythemia (ET) patients and prolonged treatment was associated with more gradual increases after the discontinuation of treatment. 2. All patients reported adverse events with imetelstat treatment. The most notable effects are neutropenia, elevated liver enzymes, fatigue, nausea, diarrhea, and dizziness. Evidence Rating Level:...

Patient Basics: Thrombocytopenia

Originally published by Harvard Health. What Is It? Thrombocytopenia is an abnormally low level of platelets in the blood. Platelets are made by the bone marrow. They help your blood to clot. People with thrombocytopenia can have excessive bleeding. This condition can occur in varying degrees. The risk of bleeding increases as the...
Image: PD 1. Mutations in the gene encoding calreticulin (CALR) were found in a majority of patients with non-JAK2, non-MPL essential thrombocythemia or primary myelofibrosis. 2. Patients with CALR mutations may have a more benign clinical course. Study Rundown: The majority of patients with essential thrombocythemia (ET) or primary myelofibrosis (PM) have...