• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home StudyGraphics

#VisualAbstract: Randomized Trial of Platelet-Transfusion Thresholds in Neonates

byStudy Graphics | C.WuandConstance Wu
August 22, 2020
in StudyGraphics
Reading Time: 1 min read
0
Share on FacebookShare on Twitter

1. Preterm infants given prophylactic platelet transfusions at thresholds below 50,000 platelets per cubic millimeter had higher risks of death or major bleeding after 28 days as compared to neonates given transfusions at thresholds below 25,000 per cubic millimeter.

2. There was no significant difference in other serious adverse events between groups.

Evidence Rating Level: 1 (Excellent)

Study Rundown: Preterm infants with thrombocytopenia are often given prophylactic platelet transfusions to reduce their risk of bleeding. However, guidelines for when to prophylactically begin platelet transfusions in preterm neonates with thrombocytopenia are currently lacking. In this randomized control trial, investigators studied the comparative effects of initiating platelet transfusions at platelet thresholds of 50,000 per cubic millimeter (high-threshold) versus 25,000 per cubic millimeter (low-threshold). The primary outcome was death or new major bleeding event within 28 days after randomization. Neonates randomized to receive platelet transfusions at below the higher-threshold had significantly higher death and major bleeding rates.

These findings may aid in creating objective threshold guidelines for platelet transfusions among neonates with thrombocytopenia. Limitations of the study include a minority of patients recruited during the first 5 days of life and possibly reduced generalizability as very few eligible patients were ultimately enrolled in the study.

Click to read the study in NEJM

©2019 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc

RELATED REPORTS

Global mortality of neonates born preterm has decreased nearly 50 percent since 1990

Noninvasive ventilation with neurally adjusted ventilatory assist (NIV-NAVA) outperforms nasal continuous positive airway pressure (NCPAP) post-extubation in preterm infants

Antenatal corticosteroids may affect neurodevelopment differently based on gestational age

Tags: neonatologyplatelet transfusionthrombocytopenia
Previous Post

Quick Take: Effect of a Multifaceted Quality Improvement Intervention on the Prescription of Evidence-Based Treatment in Patients at High Cardiovascular Risk in Brazil

Next Post

HCV-positive heart and lung transplant likely safe with post-transplant sofosbuvir-velatasivir treatment

RelatedReports

Increasing C-section room temperature linked to reduced neonatal, maternal hypothermia
Chronic Disease

Global mortality of neonates born preterm has decreased nearly 50 percent since 1990

June 15, 2022
No decrease in infant mortality with maternal micronutrient supplementation in Bangladesh
Pediatrics

Noninvasive ventilation with neurally adjusted ventilatory assist (NIV-NAVA) outperforms nasal continuous positive airway pressure (NCPAP) post-extubation in preterm infants

May 6, 2022
Abusive head trauma results in fewer productive life-years
Chronic Disease

Antenatal corticosteroids may affect neurodevelopment differently based on gestational age

April 28, 2022
Oophorectomy associated with reduced cancer risk and all-cause mortality for BRCA1/2 patients
Genetics

Rapid genotyping for variant associated with aminoglycoside-induced ototoxicity is feasible in acute neonatal setting

April 6, 2022
Next Post
Sofosbuvir-velpatasvir shows promise in HCV genotype 2 and 3 infection: The ASTRAL 2-3 study

HCV-positive heart and lung transplant likely safe with post-transplant sofosbuvir-velatasivir treatment

Insulin costs rose exponentially, regardless of formulation or patent

Quick Take: Continuous Subcutaneous Insulin Infusion Versus Multiple Daily Injection Regimens in Children and Young People at Diagnosis of Type 1 Diabetes

Earlier puberty associated with increased risk of depression in girls

Quick Take: Effectiveness of a Brief Group Psychological Intervention for Women in a Post-Conflict Setting in Pakistan

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Relugolix combination therapy is efficacious for endometriosis-associated pain
  • Age-based products and longer interdose intervals may reduce the risk of cardiac disease following COVID-19 mRNA vaccination
  • OPTN and UNOS update policy regarding hepatocellular carcinoma [Classics Series]
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.