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2 Minute Medicine | May 24, 2015

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2 Minute Medicine provides concise, curated, medical news written by health professionals. Keep up with the latest medical news on cardiology, infectious disease, pediatrics, internal medicine and more! Led by Harvard Physicians.

Single motherhood associated with poorer health outcomes in late adulthood

May 22, 2015 |

1. Single motherhood was associated with increased risk of Activities of Daily Living (ADL) limitations and poor Self-Reported Health (SRH) in late adulthood in the USA, England, and many other European countries that increased with duration of single-motherhood.

2. While in some countries, controlling for per capita income and … Read More

Age not associated with differences in radiosurgical arteriovenous malformation outcomes

May 21, 2015 |

1. There was no difference between elderly patients (≥60 years) and non-elderly patients in the occurrence of adverse outcomes following radiosurgery for arteriovenous malformation.

2. Elderly age was not predictive of arteriovenous malformation obliteration, radiation-induced changes or hemorrhage following radiosurgery.

Evidence Rating Level: 2 (Good)

Study Rundown: Cerebral arteriovenous malformation (AVM) … Read More

FDG-PET may guide antibiotic therapy in vascular graft infections

May 21, 2015 | 1

1. In a prospective cohort study of 25 patients with prosthetic vascular graft infections treated with systemic antibiotics, the use of FDG-PET/CT for monitoring of metabolic activity within the graft was effective at determining infection status and was used to alter the course of antibiotic therapy in all patients.

Evidence … Read More

STOP-IT trial supports fixed-duration antibiotic therapy for intraabdominal infections

May 20, 2015 |

1. Rates of surgical site infection, recurrent intraabdominal infection, or death within 30 days were similar in patients with intraabdominal infections receiving either 4 (fixed-duration) or up to 10 days of antibiotic therapy after adequate source control had been achieved.

2. The adherence rate to the fixed-duration antibiotic therapy … Read More

Oral prednisone improves function, not pain in acute lumbar radiculopathy

May 20, 2015 |

1. In this randomized controlled study of acute lumbar radiculopathy, oral prednisone improved function at weeks 3 and 52 when compared to placebo.

2. In this randomized controlled study, there was no difference between oral prednisone and placebo in improvement of below the waist pain at weeks 3 or 52 … Read More

Drug ameliorates effects of chronic kidney disease by targeting cell cytoskeleton [PreClinical]

May 20, 2015 |

1. Depletion of dynamin, a protein involved in maintenance of the actin cytoskeleton, resulted in decreased circulation of large proteins in zebrafish, which modeled the presence of protein in patient urine (proteinuria).

2. Administration of the small molecule Bis-T-23, which induces dynamin activity, reduced both transient and chronic proteinuria … Read More