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2 Minute Medicine | April 26, 2015

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2 Minute Medicine provides concise, curated, medical news written by health professionals. Keep up with the latest medical news on cardiology, infectious disease, pediatrics, internal medicine and more! Led by Harvard Physicians.

Prednisolone and pentoxifylline do not reduce mortality in alcoholic hepatitis [STOPAH trial]

April 23, 2015 |

1. In patients with severe alcoholic hepatitis, treatment with prednisolone or pentoxifylline did not significantly reduce mortality at 28 days. Moreover, these treatments did not reduce mortality or the need for liver transplantation at the 90-day or 1 year timepoints.

2. Patients treated with prednisolone experienced significantly higher rates … Read More

Mindfulness-based cognitive therapy is not superior to maintenance antidepressants in preventing depression recurrence or relapse [PREVENT trial]

April 23, 2015 | 1

1. This single-blind, multicenter, randomized controlled trial found that mindfulness-based cognitive therapy with support to taper or discontinue antidepressant therapy did not significantly reduce depression relapses or recurrences within 24 months of follow-up in participants diagnosed with recurrent major depressive disorder, compared to maintenance antidepressant therapy.

2. Both treatments, however, … Read More

Using adhesive strips with dermal sutures does not improve cosmesis

April 23, 2015 |

1. When comparing the cosmetic outcome of two different methods of wound closure (interrupted subcuticular sutures alone vs. the combination of overlying adhesive strips and buried interrupted subcuticular sutures), there was no appreciable difference in cosmetic outcome or scar width.

Evidence Rating Level: 1 (Excellent)      

Study Rundown: Traditional … Read More

PET scans in early-stage Hodgkin’s lymphoma may help guide therapy [RAPID trial]

April 22, 2015 |

1. In patients with negative PET scans after 3 cycles of chemotherapy, 3-year progression free survival was slightly better among those who received radiotherapy than among those who received no further treatment, though prognosis was excellent in both groups.

2. Overall survival at 3 years was equivalent between the two … Read More

Gene therapy may be helpful for Wiskott-Aldrich Syndrome

April 22, 2015 |

1. In this study of seven individuals with Wiskott-Aldrich Syndrome (WAS), gene therapy improved eczema, susceptibility to infection, autoimmunity, and T cell function.

2. While the presence of WAS protein expressing B cells may indicate an improvement in humoral immune function, the timeframe of the study was too short to … Read More

siRNA against antithrombin alleviates symptoms of hemophilia [PreClinical]

April 22, 2015 |

1. Researchers developed a small interfering RNA (siRNA) molecule targeting antithrombin (AT) production, ALN-AT3, which reduced AT concentrations in mice and monkeys when administered subcutaneously.

2. Several animal hemophilia models showed that prophylactic treatment with ALN-AT3 resulted in decreased bleeding time, increased clot sizes, and greater thrombin production as compared … Read More