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2 Minute Medicine | August 31, 2014

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Donor and recipient regulatory T-cells may promote transplant tolerance in mice

August 29, 2014 |

1. Depletion of all Foxp3+ regulatory T-cells (Tregs) induced rejection of stable skin and heart allogeneic transplants in a hematopoietic chimeric mouse model. 

2. The presence of either donor or recipient Tregs was sufficient to maintain tolerance of both skin and heart transplants. 

Evidence Rating Level: 2 (Good) 

Study Rundown:Read More

Damage similar in each eye after sequential ischemic optic neuropathy

August 29, 2014 |

1. The magnitude of retinal nerve fiber layer (RNFL) loss was similar in each eye following bilateral non-arteritic anterior ischemic optic neuropathy (NAION). 

2. Visual field loss was similar between the two eyes affected by NAION. 

Evidence Rating Level: 2 (Good)            

Study Rundown: Non-arteritic anterior … Read More

Most cancer patients may not receive adequate treatment for comorbid depression

August 28, 2014 |

1. The prevalence of major depression was highest in those with lung cancer, followed by gynecological, breast, colorectal, and genitourinary cancers.

2. Most of the cancer patients studied (73%) did not receive effective treatment for their depression.

Evidence Rating Level: 3 (Average)

Study Rundown: Major depression is commonly seen in … Read More

Collaborative care model reduces depression in lung cancer patients [SMaRT Oncology-3 Trial]

August 28, 2014 |

1. Treatment of depression in patients with lung cancer using a collaborative care model resulted in significantly lower depression severity ratings than in patients treated using usual care by their primary care physician. 

2. Lung cancer patients treated with a collaborative care model also reported improvements in self-rated depression, anxiety, … Read More