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2 Minute Medicine | November 22, 2014

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Early tube feeding unable to reduce infections in pancreatitis [PYTHON trial]

November 20, 2014 |

1. Among patients with acute pancreatitis, there was no significant difference in infections or 6-month mortality between the early tube feeding group compared to the delayed oral diet group. 2. Patients in the oral diet group had a significantly decreased amount of time before full tolerance of oral diet compared to the early nasoenteric group. […]Read More

Increased mortality observed in type 1 diabetes

November 20, 2014 |

1. In a large, prospective, observational study, overall death rate was significantly higher among patients with type 1 diabetes compared to controls, even among those with the best glycemic control. 2. There was a trend of increasing risk of death from any cause and from cardiovascular causes with higher mean glycated hemoglobin levels. Evidence Rating […]Read More

Genetically engineered lymphocytes inhibit Hepatitis C virus replication in vitro [PreClinical]

November 20, 2014 |

1. Activated suicide gene modified lymphocytes (SGMLs) inhibit Hepatitis C virus (HCV) replication multiple in vitro models of infection. 2. At low effector:target cell ratios, SGMLs inhibit HCV replication through non-cytotoxic mechanisms and are resistant to calcineurin inhibitors. Evidence Rating Level: 2 (Good) Study Rundown: Chronic HCV infections are strongly associated with severe late stage […]Read More

No benefit of adding mitral valve repair to CABG

November 19, 2014 |

1. In patients with multivessel coronary artery disease and moderate mitral regurgitation, there was no significant benefit on left ventricular reverse remodeling at 12 months with performing mitral valve repair with coronary artery bypass grafting, when compared with bypass surgery alone. 2. There was no significant difference between the two groups in the rate of […]Read More