Tag: Type 2 Diabetes Mellitus

1. In this prospective cohort study from France, consumption of ultra-processed foods (UPF) was linked to an increased risk of type 2 diabetes (T2D). 2. The association between UPF and T2D remained significant after accounting for other metabolic comorbidities and weight change. Evidence Rating Level: 2 (Good)            Study Rundown: Dietary content has...
1. Early combination therapy with vildagliptin and metformin is associated with improved glycemic durability in the setting of newly diagnosed type 2 diabetes. Evidence Rating Level: 1 (Excellent) Early glycemic control in type 2 diabetes is associated with glycemic durability and a reduced risk of developing related complications. The early introduction...
1. In this large, longitudinal cohort study from the United States, patients with poor health status were more likely to continue insulin use compared with healthier patients. Evidence Rating Level: 2 (Good) Study Rundown: Type 2 Diabetes Mellitus (DM2) is one of the most common chronic illnesses in the world. Glycemic...
1. In children with type 2 diabetes (T2DM) on metformin, those randomized to liraglutide had better glycemic control after 26 weeks compared to placebo treated patients. 2. Patients treated with liraglutide experienced more adverse events and gastrointestinal issues than placebo patients. Evidence Rating Level: 1 (Excellent)   Study Rundown: Incidence of both childhood...
1. Over a median period of almost 16 months, type 2 diabetic (T2DM) patients randomized to oral semaglutide for experienced a similar rate of cardiovascular (CV) events compared to placebo treated patients. 2. Discontinuation of therapy due to gastrointestinal issues occurred more often in the semaglutide group. Evidence Rating Level: 1...
1. In children with type 2 diabetes (T2DM) on metformin, those randomized to liraglutide had better glycemic control after 26 weeks compared to placebo treated patients. 2. Patients treated with liraglutide experienced more adverse events and gastrointestinal issues than placebo patients. Evidence Rating Level: 1 (Excellent)   Study Rundown: Incidence of both...
1. In a 15-year observational cohort study of type 2 diabetics treated with intensive compared to standard glucose control therapy the risk of major cardiovascular event or death was similar between both treatment groups. 2. There was no reported difference in health-related quality of life scores between the intensive and...
1. In this descriptive case series, 55 cases of patients with diabetes who developed Fournier gangrene while using sodium-glucose cotransporter-2 (SGLT2) inhibitors are described. 2. While neither causality nor incidence are identified in this paper, physicians prescribing SGLT2 inhibitors should be aware of the association with Fournier gangrene. Evidence Rating Level:...
1. Continued use of metformin beyond the randomized controlled trial was found to be predictive of long-term weight loss among participants who had lost at least 5 percent of their body weight during the first year of the trial. 2. The authors observed that older age and greater amount of...
1. Patients with young-onset type 2 diabetes had higher rates of all-cause hospitalization than usual-onset diabetes. Over one-third of the total hospitalization bed-days were attributable to mental illness. 2. In a retrospective model, hospitalization rates could be reduced with improved control of modifiable risk factors. Evidence Rating Level: 2 (Good) Study Rundown:...