Tag: Type 2 Diabetes Mellitus

1. Standard BMI thresholds associated with greater risk of diabetes varied across 57 low- and middle-income countries depending on geographical region. 2. Younger individuals are also at greater risk of diabetes depending on geographical region, notably for men aged 25-34 in sub-Saharan Africa.  Evidence Rating Level: 2 (Good) Study Rundown: Body mass...
1. Tirzepatide was superior to placebo with regard to changes in HbA1c, serum glucose, body weight loss, and proportion of patients achieving HbA1c targets of less than 7.0%. 2. Compared to placebo, the proportion of adverse events with tirzepatide were mildly elevated. Evidence Rating Level: 1 (Excellent) Study Rundown: In many patients...
1. In patients with type 2 diabetes, use of sodium-glucose cotransporter 2 inhibitors was associated with reduced risk of all-cause mortality compared with sulfonylureas, regardless of cardiovascular disease status, estimated glomerular filtration rate category, and albuminuria status. 2. The addition of SGLT2 inhibitor as a second-line antihyperglycemic agent with metformin...
1. Widespread diabetes screening helps to identify asymptomatic patients with preserved renal function and low diabetes-associated cardiovascular risk. 2. New cardiovascular risk stratification strategies are needed given heterogeneous characteristics of patients with type 2 diabetes.  Evidence Rating Level: 2 (Good)  Study Rundown: In the last decade, New Zealand Ministry of Health has...
1. Among adults with poorly controlled type 2 diabetes treated with basal insulin without prandial insulin, continuous glucose monitoring resulted in significantly lower hemoglobin A1c levels at 8 months when compared with conventional blood glucose meter monitoring. 2. Patients using continuous glucose monitoring also had significantly improved secondary outcomes including...
1. Matched cohort meta-analysis showed significant morality and life expectancy benefits with metabolic–bariatric surgery compared to non-surgical management of obesity. 2. Survival benefits of bariatric surgery more apparent for individuals with type 2 diabetes.  Evidence Rating Level: 1 (Excellent) Study Rundown: Metabolic syndrome has been associated with significant morbidity and mortality, increasing...
1. Younger age of onset of type 2 diabetes mellitus is strongly associated with increased risk of subsequent dementia Evidence Rating Level: 2 (Good) Study Rundown: 34.2 million Americans  (10% of the U.S. population) have type 2 diabetes mellitus, and approximately 1 in 3 American adults have pre-diabetes. While the wide...
1. An increase in childhood fat mass was more strongly associated with the risk of adult onset type 2 diabetes than childhood weight, independent of childhood height Evidence Rating Level: 2 (Good) Study Rundown: Approximately 422 million people live with diabetes worldwide, among whom more than 90% have type 2 diabetes....
1. Change in mean bodyweight was -9.6% with semaglutide 2.4 mg vs. -3.4% with placebo. 2. Approximately two-thirds of patients on semaglutide 2.4 mg achieved a target HbA1c of 6.5% or less.  Evidence Rating Level: 1 (Excellent) Study Rundown: There is strong overlap between weight gain and type 2 diabetes, with the...
1. Compared to patients of European descent, poorer health outcomes were seen among Māori and Pacific New Zealanders with type 2 diabetes. 2. Māori patients had the highest incidence rate of all-cause mortality, cardiovascular mortality, and cancer mortality. Evidence Rating Level: 2 (Good) Study Rundown: Disparities associated with ethnicity and socioeconomic status...