Tag: vaginal progesterone

1. Systematic review of RCTs demonstrates reduced rate of early preterm birth (<34 weeks) for high-risk (previous spontaneous preterm birth, short cervix) singleton pregnancies with vaginal progesterone and intramuscular 17-hydroxyprogesterone caproate (17-OHPC). 2. Efficacy of vaginal progesterone and 17-OHPC may be more effective for women with short cervices.  Evidence Rating Level:...
1. Women with a history of unexplained recurrent miscarriages who were treated with vaginal progesterone during the first trimester did not have a significant difference in rate of live births compared to those who received placebo. 2. There were no differences in terms of neonatal outcomes or anomalies between the...
Classics Series, Landmark Trials in Medicine
1. Among women with a sonographic short cervix, those randomized to receive daily vaginal progesterone were 45% less likely to experience preterm delivery prior to 33 weeks gestation (NNT=14). 2. Adverse neonatal outcomes including respiratory distress syndrome (NNT=22), low birthweight and neonatal mortality were significantly less common in the vaginal progesterone group. Original...