• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Oncology

Tiragolumab with atezolizumab is a promising treatment option for PD-L1 positive advanced non-small-cell-lung cancer

byKassandra McFarlaneandSze Wah Samuel Chan
May 23, 2022
in Oncology
Reading Time: 3 mins read
0
Share on FacebookShare on Twitter

1. Progression-free survival was longer for patients receiving tiragolumab with atezolizumab as compared to placebo

2. The combination arm had a signal of inducing increase lipase compared to atezolizumab alone

Evidence Rating Level: 2 (Good)

Study Rundown: This study explored the impact of tiragolumab with atezolizumab as compared to placebo with atezolizumab a first-line treatment for non-small-cell lung cancer (NSCLC) that is unresectable or metastatic. Atezolizumab is indicated in the first line setting for NSCLC and this study investigated the addition tiragolumab, a new antibody directed against TIGT, a new target for immune blockade to promote anti-tumour activity. Prior dual blockade with CTLA-4 and PD-1/PD-L1 improved survival over chemotherapy but were not definitively compared against single agent immunotherapy alone. Primary outcomes included progression-free survival (PFS) and objective response rate (ORR). Secondary outcomes included safety, as measured by adverse events. In the tiragolumab plus atezolizumab group, median PFS was 5.4 months as compared to 3.6 months in the placebo with atezolizumab group. ORR was higher in the treatment group compared to the placebo group. Serious treatment-related adverse events (AEs) were noted in both groups (14 patients from the test group and 12 from the placebo group). An increase in lipase was the most commonly reported severe treatment-related AE in both groups. The test group population had 2 treatment-related deaths. Limitations to this study include inadequate power regarding ORR and PFS as this was a phase 2 trial and the lack of mature data. Overall, tiragolumab with atezolizumab presents a possible first-line treatment option for PD-L1 positive advanced or metastatic NSCLC which is being confirmed in a phase 3 study and highlights the potential of TIGT inhibition as a new clinically important pathway for cancer immunotherapy.

Click to read the study in The Lancet Oncology

Relevant Reading: Nivolumab plus ipilimumab in advanced non–small-cell lung cancer.

In-Depth [randomized controlled trial]: This international, randomized, phase 2, double-blinded study conducted in centres from the USA, Asia, and Europe randomly assigned 135 adult patients with advanced unresectable or metastatic NSCLC on a 1:1 basis into two groups. Every three weeks, patients received either 600mg of tiragolumab with 1200mg of atezolizumab or placebo plus atezolizumab by intravenous. In the tiragolumab plus atezolizumab group, median PFS was 5.4 months (95% confidence interval (CI), 4.2 – not estimable), whereas in the placebo with atezolizumab group it was 3.6 months (95% CI, 2.7 – 4.4 months). In the treatment group, 21 patients (31.3%, 95 CI, 19.5-43.2%) had an objective response, as compared to 11 patients (16.2%, 95% CI, 6.7-25.7%) in the placebo group. At a median duration of follow-up of 30.4 months, the median OS in the combination therapy arm was 23.2 months vs. 14.5 months in the single agent and placebo arm (HR 0.69, 95% CI, 0.44 – 1.07, p = 0.093). Tumour proportion score (TPS) was used to subdivide the treatment response. There was improved OS in the TPS ≥50% but not in the 1-49% group. Treatment-related AEs were common in both the combination arm and comparator arms (82% vs. 71%). There was some increased grade 1-2 rash and pruritis in the combination group and some signal of increased lipase levels as well but the phase 3 study will help elucidate whether there is a higher immune-related pancreatitis adverse event in the dual blockade arm.

RELATED REPORTS

Overall survival with triplet therapy in BRAF V600 mutation-positive advanced melanoma

Atezolizumab does not reduce post-resection recurrence in patients with renal cell carcinoma

#VisualAbstract: Neoadjuvant atezolizumab is not effective for node-positive HER2⁺ breast cancer

Image: PD

©2022 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: AtezolizumabnsclcTIGTtiragolumab
Previous Post

University students perceive that Instagram improves social connection but impairs mental wellbeing

Next Post

Adebrelimab plus chemotherapy improves overall survival in extensive-stage small-cell lung cancer

RelatedReports

Complement mutation linked to poor response to eculizumab
Oncology

Overall survival with triplet therapy in BRAF V600 mutation-positive advanced melanoma

December 28, 2022
Tenofovir disoprovil fumarate HIV prophylaxis linked with minimal kidney impact
Chronic Disease

Atezolizumab does not reduce post-resection recurrence in patients with renal cell carcinoma

October 11, 2022
#VisualAbstract: Neoadjuvant atezolizumab is not effective for node-positive HER2⁺ breast cancer
StudyGraphics

#VisualAbstract: Neoadjuvant atezolizumab is not effective for node-positive HER2⁺ breast cancer

October 11, 2022
#VisualAbstract: Adjuvant pembrolizumab increased disease-free survival in completely resected, PD-L1 unselected non-small-cell lung cancer patients
StudyGraphics

#VisualAbstract: Adjuvant pembrolizumab increased disease-free survival in completely resected, PD-L1 unselected non-small-cell lung cancer patients

September 28, 2022
Next Post
Patient Basics: Lung Cancer Overview

Adebrelimab plus chemotherapy improves overall survival in extensive-stage small-cell lung cancer

Quick Take: Effect of Developmentally Adapted Cognitive Processing Therapy for Youth With Symptoms of Posttraumatic Stress Disorder After Childhood Sexual and Physical Abuse

Gratitude-focused writing may improve mental wellness during periods of chronic stress

Quick Take: Intravenous patient-controlled analgesia versus thoracic epidural analgesia after open liver surgery

Operating the day after performing surgery the previous night not associated with adverse patient outcomes

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Low-dose pirfenidone may be noninferior to standard dosing in patients with idiopathic pulmonary fibrosis
  • Protein-truncating variants in apolipoprotein B and PCSK9 genes associated with lower exposure to atherogenic LDL cholesterol and risk of coronary heart disease
  • College campus monkeypox outbreaks can be controlled with timely detection and isolation
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

Want more physician-written
medical news?

Join over 10 million yearly readers and numerous companies. For healthcare professionals
and the public.

Subscribe for free today!

Subscription options