• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • 2MM Podcast
  • Write for us
  • Contact Us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Chronic Disease

Breast cancer screening associated with substantial overdiagnosis in Danish study

byCaitlyn HuiandDeepti Shroff Karhade
January 10, 2017
in Chronic Disease, Oncology, Public Health
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

1. In this retrospective cohort, breast cancer screening was not associated with a reduction in advanced tumors.

2. Breast cancer screening was associated with higher rates of overdiagnosis of invasive breast cancer tumors and ductal carcinoma in situ (DCIS).

Evidence Rating Level: 2 (Good)

Study Rundown: The purpose of effective breast cancer screening is to reduce the incidence of advanced tumors (tumors larger than 20 mm at detection). Screening mammography detects many small tumors that would not become clinically evident over the course of the lifetime, resulting in increased rates of overdiagnosis. Considering the fact that mammography results in false positive diagnoses, determining whether breast cancer screening actually reduces the rates of advanced tumors has important therapeutic implications. The authors of this Danish study conducted a retrospective cohort evaluation to examine the association of mammography screening with incidence of advanced cancer and to estimate overdiagnosis. In general, they observed that breast cancer screening was associated with substantial overdiagnosis, with no significant reduction in advanced tumors. This study has several limitations. First, the study examined incidence of late stage tumors rather than disease-specific mortality. Additionally, regional differences complicated interpretation of the data. Overall, the study suggests that breast cancer screening does not reduce the incidence of advanced tumors. These results may have clinical implications in the future regarding preventative screening programs in Denmark and globally.

Click to read the study in the Annals of Internal Medicine

Relevant Reading: Implications of Overdiagnosis: Impact on Screening Mammography Practices

RELATED REPORTS

Abbreviated MRI is superior to whole-breast ultrasound for detection of cancer in dense breasts

Less frequent mammography is non-inferior to annual screening for breast cancer survival in women after curative treatment

False-positive mammography results may deter women from continued screening

In-Depth [retrospective cohort]: The authors conducted a retrospective cohort study utilizing data from all Danish women aged 35 to 85 diagnosed with invasive cancer during 1980 to 2010 from the Danish Breast Cancer Group (DBCD) and the Danish Cancer Registry (DCR). They utilized two different methods to analyze data. From these methods, the estimates of overdiagnosis ranged from 9.9% to 48.3%, depending on whether the estimate included DCIS, which age groups were included in the denominator, and whether trends in women too young to be screened were accounted for. The difference in the incidence rate ratio (IRR) before and after screening for women aged 35 to 49 was 0.71 (95%CI 0.71 to 0.86) for advanced cancer and 1.14 (1.05 to 1.25) for non-advanced cancer. In women aged 70-84, the IRR difference was 1.25 (1.16 to 1.34) for advanced and 1.63 (1.51 to 1.76) for non-advanced cancer.

Image: PD

©2017 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: breast cancer screeningoverdiagnosis
Previous Post

Pay-for-performance programs may be linked to process-of-care improvements in ambulatory settings

Next Post

“Weekend Warrior” physical activity patterns linked to lower mortality

RelatedReports

3D mammography (tomosynthesis) enhances accuracy of breast cancer screening
Chronic Disease

Abbreviated MRI is superior to whole-breast ultrasound for detection of cancer in dense breasts

June 25, 2025
3D mammography (tomosynthesis) enhances accuracy of breast cancer screening
Chronic Disease

Less frequent mammography is non-inferior to annual screening for breast cancer survival in women after curative treatment

April 2, 2025
Adjuvant breast cancer treatment associated with additional cancer risk
Oncology

False-positive mammography results may deter women from continued screening

September 11, 2024
Variability in interpretation of breast biopsy slides associated with low verification of atypia and ductal carcinoma in situ
Oncology

ChatGPT accurately selects imaging modality for breast cancer screening and pain assessment

June 22, 2023
Next Post
Certain financial incentive programs may promote increased physical activity

“Weekend Warrior” physical activity patterns linked to lower mortality

High incidence of foreskin morbidity in uncircumcised males

Tranexamic acid reduces bleeding risk during coronary artery surgery: The ATACAS trial

Niraparib may lengthen progression-free survival for patients with recurrent ovarian cancer

Radiolabeled somatostatin analogue linked with improved survival in neuroendocrine tumors

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Early acetaminophen use reduces mortality risk in patients with sepsis-associated encephalopathy
  • Structured Exercise after Adjuvant Chemotherapy for Colon Cancer
  • 2 Minute Medicine Rewind June 30, 2025
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
No Result
View All Result

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.