Nephrology

Reports of high-impact nephrology studies by medical professionals

Pembrolizumab improves median survival amongst those with recurrent urothelial carcinoma

1. Patients with recurrent urothelial carcinoma experienced significantly longer median survival times when treated with pembrolizumab compared with chemotherapy agents.   2. Fewer treatment-related adverse events...

AKI associated with increased mortality among critically ill children and young adults: The AWARE...

1. The study demonstrated that acute kidney injury (AKI) is common in critically ill children and young adults, and is associated with increased mortality. 2....

Fish oil and aspirin did not reduce arteriovenous fistula failure: The FAVOURED trail

1. In this multi-center, international, randomized, controlled trial, use of fish oil supplementatio at the time of arteriovenous fistula (AVF) creation was not associated...

Metformin associated with reduced mortality in kidney disease, congestive heart failure, and chronic liver...

1. Metformin use is associated with reduced all-cause mortality in patients with chronic kidney disease, congestive heart failure, or chronic liver disease with hepatic...

Sunitinib increases disease free survival in high risk renal carcinoma post nephrectomy

1. In patients with locoregional clear-cell renal cell carcinoma (RCC) at high risk of recurrence post nephrectomy, those taking sunitinib had a significantly longer...

Contrast-enhanced computed tomography associated with high sensitivity to renal stone detection

1. In a retrospective review of 72 patients with renal stones that underwent unenhanced computed tomography (CT) followed by contrast-enhance CT in the portal...

Reduced risk of hyperkalemia with sacubitril/valsartan compared to enalapril in presence of mineralocorticoid receptor...

1. In this secondary analysis of the PARADIGM-HF trial, amongst patients receiving mineralocorticoid receptor antagonists, rates of severe hyperkalemia (>6.0 mEq/L) were reduced in...

Ledipasvir-sofosbuvir may be safe treatment for kidney transplant recipients with chronic HCV

1. Ledipasvir-sofosbuvir treatment was associated with rapid chronic hepatitis C (HCV) RNA suppression. 2. Ledipasvir-sofosbuvir treatment was generally well tolerated in kidney transplant patients. Evidence Rating...

Strong evidence lacking to compare management strategies for renal artery stenosis

1. Evidence is lacking to demonstrate significant differences in mortality, progression to end-stage renal disease, rates of cardiovascular disease events, improvements in kidney function...

Vasopessin not shown to improve kidney function or clinical outcomes in septic shock

1. There was no significant difference in 28-day mortality between those receiving vasopressin vs. norepinephrine. 2. There was no significant difference in the number of...
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