Nephrology

Reports of high-impact nephrology studies by medical professionals

Homozygous complement component CD55 mutations cause novel gastrointestinal syndrome

1. Researchers used whole-exome sequencing to define the novel CHAPLE syndrome, characterized by a homozygous CD55 mutation with hyperactivation of complement, angiopathic thrombosis, and...

Lower rates of hypoglycemia in patients treated with insulin degludec

1. Treatment with insulin degludec resulted in a lower rate of overall symptomatic hypoglycemic episodes compared with insulin glargine U100. 2. Rates of nocturnal symptomatic...

Ultrasound and cystoscopy may be most cost-effective for asymptomatic microscopic hematuria

1. In this decision-analytic model-based cost-effectiveness analysis of diagnostic tools used to investigate asymptomatic microscopic hematuria (AMH), the most frequently used diagnostic tool was...

Benefits and harms of osteoporosis medications unclear for patients with CKD

1. While osteoporosis medications may have some benefits in chronic kidney disease patients (CKD), the evidence is unclear with respect to their impact on...

Attenuation values may help differentiate renal neoplasm from simple cyst on contrast-enhanced CT

1. In a retrospective review of 125 patients with primary renal cell neoplasm that underwent computed tomography (CT), simple renal cysts were found to...

Pembrolizumab improves median survival amongst those with recurrent urothelial carcinoma

1. Patients with recurrent urothelial carcinoma experienced significantly longer median survival times when treated with pembrolizumab compared with chemotherapy agents.   2. Fewer treatment-related adverse events...

AKI associated with increased mortality among critically ill children and young adults: The AWARE...

1. The study demonstrated that acute kidney injury (AKI) is common in critically ill children and young adults, and is associated with increased mortality. 2....

Fish oil and aspirin did not reduce arteriovenous fistula failure: The FAVOURED trail

1. In this multi-center, international, randomized, controlled trial, use of fish oil supplementatio at the time of arteriovenous fistula (AVF) creation was not associated...

Metformin associated with reduced mortality in kidney disease, congestive heart failure, and chronic liver...

1. Metformin use is associated with reduced all-cause mortality in patients with chronic kidney disease, congestive heart failure, or chronic liver disease with hepatic...

Sunitinib increases disease free survival in high risk renal carcinoma post nephrectomy

1. In patients with locoregional clear-cell renal cell carcinoma (RCC) at high risk of recurrence post nephrectomy, those taking sunitinib had a significantly longer...
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