• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • 2MM Podcast
  • Write for us
  • Contact Us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Cardiology

Statins for primary prevention may reduce morbidity and mortality in elderly

byKenan Celtik, MSandSai Folmsbee
April 21, 2015
in Cardiology, Chronic Disease
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

1. A computer simulation shows that the use of statins for primary prevention in those older than 75 years of age may reduce coronary heart disease-related morbidity and mortality.

2. The net cost benefit of all primary prevention strategies in the elderly were highly dependent on the assumptions made regarding functional limitation and cognitive impairment due to statin use.

Evidence Rating Level: 2 (Good)

Study Rundown: The guidelines for the use of statins, a class of cholesterol-lowering drugs, in people over 75 years old are inconsistent and little is known about their effectiveness in primary prevention. In this study, a computer model was employed to study the effect of statin-based primary prevention strategies in 75 to 94 year-old Americans without cardiovascular disease (CVD) over 10 years, as compared to secondary prevention in people with existing CVD. Over the next 10 years, the model predicted that these elderly Americans will experience 2.5 million myocardial infarctions, 3.1 million coronary heart disease-related deaths, and accumulate $881 billion in CVD-related costs. The simulation showed that statins for primary prevention at three different LDL-cholesterol thresholds could avoid many of the MIs and CHD-related deaths, and may be cost-saving in some demographic subgroups when compared to secondary prevention. However, the cost-effectiveness of the primary prevention strategies was highly sensitive to small changes in the assumptions regarding adverse effect profile of statins. This was the major limitation of the study, as only the two most well-documented adverse effects were incorporated into the model, which may underestimate the overall burden of functional limitation due to statins.

Click to read the study, published today in the Annals of Internal Medicine

Relevant Reading: Long-term Cost-effectiveness of Statin Treatment for Primary Prevention of Cardiovascular Disease in the Elderly.

RELATED REPORTS

The 2 Minute Medicine Podcast Episode 45

Monoclonal antibody CIS43LS efficacious in preventing malaria in Mali

Comprehensive cardiovascular disease screening does not reduce incidence of death in men aged 65 to 74

In-Depth [computer simulation]: This study modeled the disease burden and cost-benefit of statins in 75 to 94 year-old individuals in the United States using the Cardiovascular Disease Policy Model. The effects of statins were based on 3 estimates using the PROSPER randomized trial results, and the Consumer Price Index was used to inflate costs to 2014 costs. Furthermore, drug costs were derived from the National Average Drug Acquisition Cost (NADAC) database, and the average of multiple studies was used to determine the prevalence of mild cognitive impairment and functional limitation from myopathy due to statin use. In this simulation, giving statins to all adults aged 75 to 94 with a history of cardiovascular disease (i.e., secondary prevention) who weren’t already using a statin prevented 53,000 MIs, avoided 85,000 CHD-deaths, gained 269,000 disability-adjusted life years (DALYs) and decreased societal costs by $14 billion. The primary prevention strategies tested were giving every person in the age group statins, only every person with diabetes, and only people with LDL-C levels of ≥4.91, ≥4.14 and ≥3.36.

Image: PD

©2015 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: preventionstatins
Previous Post

Computerized clinical decision support may improve appropriate use of diagnostic radiology

Next Post

Normal thyrotropin levels not associated with coronary heart disease

RelatedReports

The 2 Minute Medicine Podcast Episode 15
2MM Podcast

The 2 Minute Medicine Podcast Episode 45

July 29, 2024
RTS,SA/S01 anti-malarial vaccine efficacy wanes significantly over time
Infectious Disease

Monoclonal antibody CIS43LS efficacious in preventing malaria in Mali

November 23, 2022
Cardiology

Comprehensive cardiovascular disease screening does not reduce incidence of death in men aged 65 to 74

October 20, 2022
Intrauterine Zika virus infection associated with significant fetal brain abnormalities
Chronic Disease

Monoclonal antibody L9LS prevents malaria infection in adults

August 11, 2022
Next Post
Shorter time to angioplasty may improve heart attack outcomes

Normal thyrotropin levels not associated with coronary heart disease

Opioid policy changes associated with decreased prescription overdose, increased heroin overdose

Opioid policy changes associated with decreased prescription overdose, increased heroin overdose

No association between MMR vaccination and autism regardless of baseline risk

No association between MMR vaccination and autism regardless of baseline risk

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Structured Exercise after Adjuvant Chemotherapy for Colon Cancer
  • 2 Minute Medicine Rewind June 30, 2025
  • Weighted vests and resistance training confer similar outcomes for bone density in the elderly
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
No Result
View All Result

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.