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2 Minute Medicine Rewind Jan 25, 2021

...t in health behaviours towards a sedentary lifestyle, poor dietary patterns, and increased screen time. Less is known about the impact of blood pressure and/or weight, specifically fat distribution, on retinal microvasculature at a younger age. In this ongoing population-based cohort study, as a subset of the Hong Kong Children Eye Study, 1006 children aged 6 to 8 years underwent full ophthalmic and physical examinations as well as standardized in...

2 Minute Medicine Rewind March 1, 2021

...or iron deficiency in patients newly diagnosed with HF and during follow-up, and only recommends intravenous iron supplementation for patients with HF with reduced ejection fraction (HFrEF) diagnosed with ID. However, little is known about how these guidelines are implemented in clinical practice. In this French observational, transversal multicentre trial, data from 2822 patients, who were hospitalized at least once for HF in the last five years...

2 Minute Medicine Rewind June 14, 2021

...el: 2 (Good) Postpartum mental illness affects approximately 1 in 5 mothers, and can present as anxiety, depression, bipolar disorder, psychotic disorders, alcohol and or substance abuse. This emotional burden on mothers also represents a clinical burden on the health care system with increasing rates due to the COVID-19 pandemic. This study aimed to better understand the extent of this exasperation by comparing pre and current pandemic data. In t...

2 Minute Medicine Rewind January 11, 2021

...solute risk were viral pneumonia, respiratory failure, acute kidney failure, and sepsis. 2. Complications highly associated with COVID-19 with low absolute risk were myocarditis, pneumothorax, and disseminated intravascular coagulation. Evidence Rating Level: 2 (Good) During the COVID-19 pandemic, greater than 50 million individuals worldwide have been diagnosed with the disease. Although most people present with mild or no symptoms, 20% of patien...

2 Minute Medicine Rewind March 8, 2021

...As well, previous studies have focused more on warfarin use after bleeding, and not so much on direct OACs (DOACs), which are the primary preventative measure for stroke due to atrial fibrillation. Therefore, the current study aimed to compare bleeding, thrombosis, and all-cause mortality outcomes between patients who did or did not resume OACs, after a bleeding event related to OAC use. Data was gathered between 2012 and 2017 from patients aged...

2 Minute Medicine Rewind April 5, 2021

...s of a major adverse cardiovascular event, diabetes, chronic kidney disease, and chronic liver disease. Evidence Rating Level: 2 (Good) Much of the research on post-COVID syndrome, or the long-term effects of COVID-19, have been focused on respiratory illness. However, there is growing evidence demonstrating effects on other organ systems and patterns of disease. To assess the epidemiology of post-COVID syndrome, the current study based in England...

2 Minute Medicine Rewind April 26, 2021

...e associated with an increased risk of gastrointestinal (GI) bleeds, sepsis, and pneumonia during the first month of therapy initiation. Evidence level rating: 2 (Good) Oral corticosteroids are commonly prescribed to children for various inflammatory conditions, including asthma, inflammatory bowel disease, and bronchitis. Though the adverse effects of long-term corticosteroid use have been thoroughly explored in scientific literature, the short-t...

2 Minute Medicine Rewind February 8, 2021

...ed greater radiographic severity, female sex, greater knee pain, higher BMI, and older age. Evidence Rating Level: 2 (Good) Knee osteoarthritis (OA) has a peak prevalence at age 50 worldwide, which dramatically impacts middle-aged individuals in terms of quality of life and ability to work. Currently, the use of total knee replacement (TKR) is on the rise for middle-aged patients, although TKR done too early has been linked to lower patient satisf...

2 Minute Medicine Rewind March 16, 2020

...on rate (GFR), an integral component of establishing drug dosing, prognosis, and treatment of patients with kidney disease, is often measure indirectly through serum creatinine levels to develop an estimate (eGFR). This estimation is adjusted by height, weight, age, sex, and race due to the susceptibility of serum creatinine to muscle mass, diet, and GFR. This investigation of a pooled data set from 10 studies of individuals with and without chron...

2 Minute Medicine Rewind June 15, 2020

...rugs of choice. DOACs are known to be substrates of CYP3A4 enzyme complexes, and are thus susceptible to potentially dangerous drug-drug interactions. This retrospective cohort study involved 24,943 older adults (M [SD] age = 77.6 [7.2] years, 51.0% women) living in Ontario, Canada, taking DOACs, and assessed whether co-prescription of either clarithromycin or azithromycin, macrolide antibiotics commonly prescribed for respiratory infections and k...

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