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The Classics in Medicine™: Summaries of the Landmark Trials | Search Directory

...such as The Classics in Cardiology™ , Classics in Radiology™ , etc. Over 500 landmark trial summaries included! Support the The Classics Series™ by buying the paperback or e-book editions: The Classics in Medicine™ (First Ed., ISBN 978-0996304290) The Classics in Radiology™ (First Ed. ISBN 978-0996304283) All content © 2021 2 Minute Medicine, Inc. | Boston, MA | Main Directory Unlimited Reading for Subscribers | Need Group Access? Email info@2min...

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...diabetes-related morbidity and mortality“,”The Lancet, 1998\nBMJ, 1998″,”20000″,”1.\tFor patients with type 2 diabetes mellitus, pharmacologic blood glucose control with sulfonylureas or insulin significantly reduces the risk of microvascular complications, but not macrovascular complications\n2.\tMetformin therapy is associated with significant reductions in diabetes-related and all-cause mortality; thus, it is considered first-line therapy for...

2 Minute Medicine Rewind September 20, 2021

...(IQR) age being 51 (33-72) years. In the baseline and reversion periods, 10.9% and 12.8% of PVCs were in place for more than 4 days, compared to 20.4% of PVCs for the intervention period (p < 0.001). The number of PVC-days per month were consistent across the study periods, but the number of PVCs per month were decreased in the intervention period. There were 46 PVC-BSIs during the intervention period, and the risk of PVC-BSIs was significantly g...

2 Minute Medicine Rewind September 6, 2021

...l dysfunctions (n=21 [35.6%] vs n=3450 [23.8%]; odds ratio, 1.77; 95% CI, 1.04-3.02). Furthermore, sepsis patients were at higher risk of postpartum hemorrhage, maternal ICU admissions, and preeclampsia compared to their non septic counterparts. As previously mentioned, prior studies have focused primarily on immediate maternal morbidity and mortality. Therefore, a strength of this study was its focus on obstetric and postpartum health as well as...

2 Minute Medicine Rewind June 28, 2021

...ndividuals qualified for shielding, 2.9% received a diagnosis of COVID-19, 0.2% entered critical care, and 0.7% died. When compared to the no risk category, the severe COVID-19 rate ratio was 3.21 (95% CI 3.01-3.41, p < 0.001) for moderate risk and 6.3 (95% CI 5.8-6.8, p < 0.001) for very high risk (shielding eligible) patients. Within the shielding category, solid organ transplant patients were at the great risk, with a rate ratio of 13.4 (95% CI...

2 Minute Medicine Rewind May 31, 2021

...as COVID-19 period. In total, 36,691 emergency room visits were included, 40.2% of which were for appendicitis. The results showed that there was a decrease in all visits at the start of the pandemic, but 5 weeks in, the visits for cholecystitis were returning to normal. The incident rate ratio (IRR) ranged from 0.60-0.76 for the first 3 weeks. For ectopic pregnancy, visits were below the historical volume for 3 weeks during the COVID-19 period, w...

2 Minute Medicine Rewind October 12, 2020

...h 36 deaths in the intervention and 45 deaths in the placebo (hazard ratio 0.81, 95% CI 0.59 to 1.11, p = 0.18). With regards to safety, there was no difference in arterial thrombotic complications and myocardial infarction, although 8 adverse events occurred in the treatment group, compared to 21 in the placebo group. In some cases, 30-day mortality was lowered in the treatment compared to the placebo, such as when 2 g of additional tranexamic ac...

2 Minute Medicine Rewind August 9, 2021

...hort study assessed 2 465 387 pregnancies in Ontario, Canada between June 2002 and December 2020. Among this cohort, the mean birth rates were reported as 7.96% for preterm births and a stillbirth rate of 0.56%. This data was extrapolated from population health administrative databases over the past 17.5 years. Specifically, from the Canadian Institute for Health Information’s Discharge Abstract database (CIHI-DAD) as well as the Ontario Mother-Ba...

2 Minute Medicine Rewind June 29, 2020

...experience chronic pain than those exercising less than once weekly (OR = 0.65, 95% CI = 0.53-0.78). For men, exercising nearly every day did not lower the risk for chronic pain as much as only 2-3 times per week (OR = 0.79, 95% CI = 0.65-0.98), whereas for women, exercising nearly every day lowered the risk for chronic pain the most (OR = 0.79, 95% CI = 0.70-0.88). The strength of these findings were only minimally impacted after adjusting for l...

2 Minute Medicine Rewind December 7, 2020

...in London, Ontario with a self-reported pain score of at least 40 mm on a 100 mm visual analogue scale (mean pain score was 60±18 mm for HBB, and 62±17 mm for acetaminophen). The primary outcome was pain score 80 minutes after administering the analgesic, to reflect the drugs’ peak action. Overall, the results showed no difference in pain score: For HBB, the mean score was 29±26 mm, while for acetaminophen, it was 30±29 mm. The adjusted difference...

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