Use of psychiatric medications may be associated with a higher risk of amyotrophic lateral sclerosis
1. Prediagnostic use of anxiolytics, hypnotics, sedatives and antidepressants were associated with a higher risk of amyotrophic lateral sclerosis (ALS). Evidence Rating Level: 2 (Good) While ALS has been historically...
Nivolumab plus ipilimumab improves survival over lenvatinib or sorafenib in liver cancer
1. Median overall survival was 3.1 months greater in the nivolumab plus ipilimumab group. 2. Grade 3-4 treatment-related adverse events were similar between both groups. Evidence Rating Level: 1 (Excellent)...
Dapagliflozin may improve outcomes in patients with metabolic dysfunction-associated steatohepatitis
1. The use of dapagliflozin in patients with metabolic dysfunction-associated steatohepatitis (MASH) resulted in a higher proportion of improvement of MASH compared to placebo. Evidence Rating Level: 1 (Excellent) Therapeutic...
Early induction of labour reduces shoulder dystocia rates in large for gestational age fetuses
1. Shoulder dystocia was less common in the early induction group compared to standard care. 2. Serious adverse events were comparable between the two groups. Evidence Rating Level: 1 (Excellent)...
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Exenatide does not slow Parkinson’s disease progression compared to placebo
1. There was no significant difference in functional outcome between both groups at 96 weeks. 2. Exenatide was safe...
Triptans may be the most effective treatments available for acute episodic migraine
1. In this systematic review and meta-analysis, the combination of triptans and non-steroidal anti-inflammatory drugs (NSAIDs) was the most...
AAV9.LAMP2B gene therapy shows clinical benefit in Danon disease
1. In seven patients with Danon disease, a single infusion of adeno-associated virus serotype 9 carrying transgene LAMP2B (AVV9.LAMP2B)...
Coronary CT-angiography-guided management improves outcomes in patients with stable chest pain
1. Composite of coronary heart disease death and non-fatal myocardial infarction was less frequent in the CCTA group compared...