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Quick Take: Randomized Phase II Trial Comparing Site-Specific Treatment Based on Gene Expression Profiling...

...empirical treatment, although this study was limited in that there was an imbalance in predicted tumor types between the two arms. Stratification based on predicted tumor types may also be useful in future studies. Click to read the study in JCO Image: PD ©2019 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be con...

Special Rewind: COVID-19 Vaccine Edition. December 21, 2020

...rst to Receive Emergency Use Authorization to Prevent COVID-19 On December 11, 2020, the U.S. Food and Drug Administration (FDA) approved for emergency use the first vaccine to prevent coronavirus disease 2019 (COVID-19).1 This vaccine includes BNT162b2, a lipid nanoparticle-formulated, nucleoside-modified RNA and encodes a prefusion stabilized, membrane-anchored SARS-CoV-2 full-length spike protein.2 The safety and efficacy of this vaccine, funde...

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...chronic liver disease and cirrhosis [Classics... mdssuper1597 - July 16, 2013 0 1. The Child-Pugh score consists of five clinical features and is used to assess the prognosis of chronic liver disease and cirrhosis. 2. The Child-Pugh... The CLOT trial: Dalteparin versus warfarin [Classics Series] Aimee Li, MD - December 7, 2014 0 The NICE-SUGAR trial: Intensive glycemic control harmful in the ICU [Classics Series] Andrew Cheung, MD MBA - January 1...

Coronary angioplasty safe and effective at facilities without on-site cardiothoracic surgery

...otal of 24,387 patients at 59 VA facilities underwent PCI between October 2007 and September 2010. 6,616 patients underwent PCI at facilities without on-site CT surgery and 17,771 at facilities with on-site CT surgery. Patients undergoing PCI at facilities without on-site CT surgery had lower rates of past MI, cardiac risk factors, and non-cardiac co-morbidities as well as higher rates of high-risk (Type C) stenosis and CTO. These patients (40.2%)...

Nonemergent percutaneous coronary intervention safe without on-site cardiac surgery services

...n-site cardiac surgery, compared to 9.4% with on-site cardiac surgery (p<0.001 for noninferiority). The MACE rates at 12 months were 17.3% vs 17.8% (p<0.001 for noninferiority). Additionally, angiographic review showed no difference in procedural success rates between cohorts. Outcomes varied among hospitals, with median odds of 1.3 at 12 months– suggesting MACE may be 1.3 times as likely at one facility compared to another. The median odd was 1.5...

2 Minute Medicine Rewind February 8, 2021

...fter high tibial osteotomy: time-to-event analysis and predictors 1. 5 and 10 years after undergoing a high tibial osteotomy procedure, 95% and 79% of knee osteoarthritis patients respectively did not require a total knee replacement. 2. Preoperative factors associated with an increased rate of conversion to total knee replacement included greater radiographic severity, female sex, greater knee pain, higher BMI, and older age. Evidence Rating Leve...

2 Minute Medicine Rewind January 21, 2019

...no associated increase in risk of dyslipidemia (aHR 0.87, 95% CI 0.75 to 1.00). The risk of cardiometabolic disorders was greater in males (aHR 2.13, 95% CI 2.01 to 2.26) than in females (aHR 1.79, 95% CI 1.64 to 1.96). The cumulative incidence of any cardiometabolic disorder was 52.5% for individuals with TS or CTD (95% CI 47.7% to 57.4%) in comparison to 29.5% for the general population (95% CI 29.3% to 29.6%). In terms of antipsychotic use, inv...

Updated SYNTAX score II 2020 provides accurate risk stratification for mortality and cardiovascular events

1. The revalidated SYNTAX score II 2020 was effective at predicting 10-year all-cause mortality in patients undergoing percutaneous coronary intervention (PCI) vs. coronary artery disease bypass graft (CABG). 2. The SYNTAX score II 2020 proved effective at predicting major cardiovascular events (all-cause death, non-fatal stroke, non-fatal myocardial infarction) 5-years post-procedure. Evidence Rating Level: 2 (Good) Study Rundown: As one of heal...

2 Minute Medicine Rewind April 12, 2021

...-related quality of life was significantly improved among those undergoing 10-kHz spinal cord stimulation, compared to conventional medical management. 2. Outcomes in pain relief were sustained through the six-month follow-up. Evidence Rating Level: 1 (Excellent) The global prevalence of diabetes is approximately 8.5% and it is estimated that roughly 20% of this group will develop painful diabetic neuropathy (PDN). This progressive pain condition...

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