• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • 2MM Podcast
  • Write for us
  • Contact Us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Infectious Disease

Antipsychotic medication analysis among older adults with infection-related delirium

byKeerthana PasumarthiandAlex Chan
February 24, 2023
in Infectious Disease, Psychiatry
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

Antipsychotic Medication Use Among Older Adults Following Infection-Related Hospitalization

1. In patients with newly initiated antipsychotic medications following infection-related hospitalization, discontinuation rates were lower among atypical antipsychotic users compared to haloperidol users.

Evidence Rating Level: 2 (Good)

Delirium, characterized by an acute change in mental status and cognition, presents a significant health care burden. In a hospital setting, delirium is often associated with increased mortality, functional decline, and a prolonged admission. Infection is frequently an underlying cause for delirium onset. Antipsychotic medications are commonly prescribed to manage any behavioral concerns that may arise from delirium; however, these agents are associated with adverse outcomes such as death, cardiac arrythmias, urinary dysfunction, and pneumonia. At present, there is limited information regarding factors leading to a discontinuation of antipsychotics used for delirium, which this retrospective cohort study aimed to assess. This study utilized data from the Optum’s deidentified Clinformatics Data Mart database. This paper included 5835 patients who were aged 65 and older who had a new prescription of oral antipsychotic medication within 30 days of hospital discharge. Patients who had prior use of antipsychotic medication to treat other conditions such as schizophrenia and other psychiatric disorders were excluded. The primary outcome was discontinuation of the antipsychotic medication which was defined as a gap of more than 15 days following the end of a prescription dispensing. The results of this study showed that the incidence of discontinuation within 30 days of antipsychotic initiation was 11.4% (95%CI 10.4-12.3%) among patients using atypical antipsychotics and 52.1% (95%CI 48.2-55.7%) among haloperidol users. Dementia and prolonged hospitalization were also found to be inversely associated with the discontinuation of antipsychotic medications. In conclusion, patients started on haloperidol within the hospital were more likely to discontinue this within 30 days of discharge compared to individuals started on an atypical antipsychotic. However, there are several limitations of this study that should be noted. For instance, antipsychotics started during a hospital visit may be due to reasons other than delirium onset, which was not assessed by this study. Future studies assessing this limitation can confirm antipsychotic efficacy and discontinuation rates between various medication classes.

Image: PD

©2023 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

RELATED REPORTS

Hypotension- and hypertension-avoidance strategies may yield similar neurocognitive outcomes following noncardiac surgery

No difference between pharmacologic treatments in age-related macular degeneration risk reduction

Patients with varicose veins may be at an increased risk of dementia

Tags: antipsychoticsdeliriumgeriatrics
Previous Post

#VisualAbstract: Treatment with ivermectin does not improve time to sustained recovery in outpatients with mild to moderate COVID-19

Next Post

Implantable loop recorder screening for atrial fibrillation associated with increased diagnosis of bradyarrhythmia and pacemaker implantations – A post-hoc analysis of the LOOP randomized clinical trial

RelatedReports

Prevalence of hypertension among adolescents varies by race and BMI
Chronic Disease

Hypotension- and hypertension-avoidance strategies may yield similar neurocognitive outcomes following noncardiac surgery

June 14, 2025
Quick Take: Association of Visual Impairment With Economic Development Among Chinese Schoolchildren
Chronic Disease

No difference between pharmacologic treatments in age-related macular degeneration risk reduction

May 8, 2025
Cardiology

Patients with varicose veins may be at an increased risk of dementia

May 5, 2025
Quick Take: Functional Outcome of Intravenous Thrombolysis in Patients With Lacunar Infarcts in the WAKE-UP Trial
Weekly Rewinds

2 Minute Medicine Rewind March 24, 2025

March 25, 2025
Next Post
Atrial fibrillation-specific management increases days alive and out of hospital

Implantable loop recorder screening for atrial fibrillation associated with increased diagnosis of bradyarrhythmia and pacemaker implantations – A post-hoc analysis of the LOOP randomized clinical trial

2 Minute Rewind November 29, 2021

2 Minute Medicine Rewind February 27, 2023

Adaptive ventilation for central sleep apnea linked to increased mortality in heart failure patients

Postoperative supplemental oxygen in liver transplantation not associated with reduced infection risk

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Artificial intelligence based clinical decision systems are safe and effective for diabetes management
  • Epic Launchpad propels generative-AI into everyday hospital routines
  • #VisualAbstract: Routine Cerebral Embolic Protection Did Not Reduce Stroke Incidence during Transcatheter Aortic-Valve Implantation
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
No Result
View All Result

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.