• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Pulmonology

Aspirin does not decrease the incidence of ARDS in at-risk patients

byLauren KoandMichael Milligan
May 22, 2016
in Pulmonology
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

1. Among at-risk patients in the emergency department, administration of aspirin within 24 hours of presentation was not associated with a reduction in the incidence of acute respiratory distress syndrome (ARDS).

Evidence Rating Level: 2 (Good)       

Study Rundown: ARDS, characterized by the rapid development of respiratory failure, is a common occurrence in the critical care setting and is associated with a high mortality rate. While the pathophysiology of this condition has been well established, there remains little known about how best to prevent it. Therefore, this study sought to determine whether early aspirin administration among at-risk patients could prevent the development of ARDS.

In a cohort of patients with known risk factors for ARDS, aspirin administration within 24 hours of presentation to the emergency department was not associated with a significant reduction in the incidence of ARDS after 7 days. Furthermore, the study found no significant differences in secondary outcomes or adverse events between aspirin administration and placebo. The results of this phase 2b trial therefore did not support continuation to a larger phase 3 trial.

This study was limited by a relatively low observed incidence of ARDS, which may affect its validity among more severely ill patients. Nevertheless, aspirin appears unlikely to reduce the incidence of ARDS in at-risk patients, and that further research is necessary to identify alternative therapies which can successfully prevent the development of ARDS.

Click to read the study in JAMA

Relevant Reading: Preventing ARDS: Progress, Promises, and Pitfalls

RELATED REPORTS

#VisualAbstract: Higher mean arterial blood pressure targets did not improve outcomes in comatose survivors of cardiac arrest

Risk factors and rates of post-intensive care syndrome for patients with out-of-hospital cardiac arrest

Post-intensive care syndrome risk in out-of-hospital cardiac arrest patients

In-Depth [randomized controlled trial]: This double-blind placebo controlled randomized trial enrolled 400 patients at 16 US academic hospitals. These patients were all deemed at risk for ARDS, according to the Lung Injury Prediction Score. Patients who were already receiving antiplatelet therapy and patients who presented with ARDS at the time of screening were excluded from the trial. Patients underwent 1:1 randomization, receiving either placebo or treatment with aspirin in the form of a 325 mg loading dose followed by 81 mg/day within 24 hours of presentation to the ED, and continued until hospital day 7, discharge, or death. The primary outcome was ARDS development by study day 7, and the secondary outcomes included hospital and ICU length of stay, 28-day and 1-year survival, ventilator-free days, and ARDS-associated serum biomarker (i.e., Ang-2, IL-2, IL4, etc.) changes. Among the 390 patients eventually analyzed, administration of aspirin did not significantly reduce ARDS incidence by hospital day 7 as compared to patients treated with placebo (OR 1.24; 92.6%CI 0.67-2.31). In addition, there were no differences seen in either adverse events (i.e., bleeding related events, renal failure, change in GFR) or secondary outcomes.

Image: CC/Wiki

©2016 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: ARDSintensive care
Previous Post

Endobronchial coiling for emphysema associated with moderate improvement in exercise tolerance

Next Post

Seasonal temperature variations may affect glucose tolerance in pregnancy

RelatedReports

#VisualAbstract: Higher mean arterial blood pressure targets did not improve outcomes in comatose survivors of cardiac arrest
StudyGraphics

#VisualAbstract: Higher mean arterial blood pressure targets did not improve outcomes in comatose survivors of cardiac arrest

October 27, 2022
Cardiology

Risk factors and rates of post-intensive care syndrome for patients with out-of-hospital cardiac arrest

October 21, 2022
Cardiology

Post-intensive care syndrome risk in out-of-hospital cardiac arrest patients

October 21, 2022
Using HEART score to risk stratify patients with chest pain is safe but underutilized in the ED
Weekly Rewinds

2 Minute Medicine Rewind October 17, 2022

October 17, 2022
Next Post
Late gestation antidepressant use linked to postpartum hemorrhage

Seasonal temperature variations may affect glucose tolerance in pregnancy

Confounding influences phototherapy’s association with increased childhood cancer risk

Confounding influences phototherapy’s association with increased childhood cancer risk

Ultrasound enhances gastrointestinal absorption of drugs at low frequencies

Opioid analgesics not linked to clinical improvement in chronic low back pain

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • BNT162b2 booster is safe and reduces COVID-19 transmission in older adults
  • Bisphosphonates, denosumab, abaloparatide, teriparatide, and romosozumab reduce postmenopausal fracture risk
  • Epstein-Barr viral load monitoring reduces risk of post-liver transplant lymphoproliferative disease
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

Want more physician-written
medical news?

Join over 10 million yearly readers and numerous companies. For healthcare professionals
and the public.

Subscribe for free today!

Subscription options