A novel therapy targeting γ-aminobutyric acid is safe and may be effective in major depressive disorder
1. H3-10353, a novel γ-aminobutyric acid (GABA) positive allosteric modulator, is safe and well-tolerated in healthy patients and those with...
A lower volume of polyethylene glycol with ascorbate (MoviPrep) may improve bowel cleansing prior to colonoscopy
1. 1 litre polyethylene glycol with ascorbate (1L-PEG-Asc) showed superior bowel cleansing efficacy compared to 2 litre polyethylene glycol with...
2 Minute Medicine Rewind May 25, 2026
Validation of 2 Syncope Risk Scores and Comparison With Physician Risk Estimation 1. The Canadian Syncope Risk Score (CSRS) and...
Treatment of chronic low back pain and disc herniation with amoxicillin-clavulanate (Augmentin) may not be effective for pain control
1. In adult patients with chronic low back pain (LBP) and disc herniation on magnetic resonance imaging (MRI), treatment with...
Adjuvanted influenza vaccines and high-dose influenza vaccines may have similar effectiveness in adult patients
1. Adjuvanted influenza vaccines did not differ significantly in effectiveness compared to high-dose influenza vaccines against laboratory-confirmed influenza and influenza-related...
Resuscitative endovascular balloon occlusion of the aorta may not improve outcomes in adults with non-traumatic out-of-hospital cardiac arrest
1. Resuscitative endovascular balloon occlusion of the aorta (REBOA) as an adjunct to advanced life support (ALS) does not improve...
Use of selective serotonin reuptake inhibitors guided by pharmacogenetic testing may improve treatment response in depression
1. Genotype-guided prescribing of selective serotonin reuptake inhibitors (SSRIs) may improve treatment response in children and adults with depression. Evidence...
Sequential compared to upfront treatment of metastatic colorectal cancer using oxaliplatin (Eloxatin) therapy may lead to similar outcomes
1. Sequential and upfront treatment of metastatic colorectal cancer (mCRC) with oxaliplatin (OX)-based therapy does not lead to significantly different...
Point-of-care ultrasound may be effective at identifying nephrolithiasis in the emergency department
1. Renal point-of-care ultrasound (rPOCUS) findings of hydronephrosis in adult patients presenting to the emergency department (ED) with suspected renal...
2 Minute Medicine Rewind May 11, 2026
Adjuvanted vs High-Dose Influenza Vaccines in Older US Adults 1. Adjuvanted influenza vaccines did not differ significantly in effectiveness compared...
