Protein therapy combined with stem cell transplantation repairs stroke-induced brain damage [PreClinical]
1. Neural stem cell (NSC) transplantation and subsequent treatment with a variant of activated protein C (3K3A-APC) improved engraftment...
New treatment target for paclitaxel-induced pain [PreClinical]
1. In mouse models, the lipid metabolite 9,10 EpOME was identified as an important mediator of paclitaxel-induced peripheral neuropathic pain...
Correcting NAD+ depletion may improve muscular degeneration in Duchenne muscular dystrophy [PreClinical]
1. Dietary supplementation with nicotinamide riboside (NR), a form of vitamin B3 that acts as a precursor to nicotinamide adenine...
Small molecule inhibitor may resolve parasitic infections of neglected tropical diseases [PreClinical]
1. In several mouse models, a novel small molecule inhibitor, GNF6702 (GNF), effectively cleared infections of parasites that cause leishmaniasis,...
![Nanoparticle delivery of aurora kinase inhibitor may improve tumor treatment [PreClinical]](https://www.2minutemedicine.com/wp-content/uploads/2016/02/20541_lores-350x250.jpg)
Antibody decreases Zika virus levels and fetal transmission [PreClinical]
1. Antibodies were isolated from patients with prior Zika virus infection and one specific antibody, ZIKV-117, decreased fetal transmission of...
![Engineered stem cells mitigate liver damage caused by radiation [PreClinical]](https://www.2minutemedicine.com/wp-content/uploads/2014/12/Human_embryonic_stem_cells-350x250.png)
Stem cell transplant in primates treats injured hearts [PreClinical]
1. After undergoing a transient myocardial infarction (MI), primates injected with stem cells showed improved heart function. 2. None of...
Combination therapy effectively treats hepatocellular carcinoma in mice [PreClinical]
1. When combined with hepatic artery ligation, the current treatment for hepatocellular carcinoma (HCC), tirapazimine (TPZ) was found to...
New peptide-modified hydrogel developed for diabetic wound healing [PreClinical]
1. The peptide QHREDGS protected human epithelial cells from oxidative stress and promoted cell migration and survival. 2. When a...
Blocking fatty acid synthesis may curb lung cancer growth [PreClinical]
1. ND-646, a small molecule inhibitor of FASyn, an enzyme involved in fatty acid synthesis, caused reduced growth and viability of...
Targeted thyroid hormone delivery reduces off-target effects [PreClinical]
1. Delivery of a hybridized form of glucagon and the thyroid hormone T3 (G/T3) improved signs of metabolic syndromes including...
