Balloon-guided catheters are associated with worse outcomes in large vessel thrombectomy
1. Functional recovery at 90 days was lower in the balloon-guided catheter group versus the conventional catheter group. 2. All-cause...
Pembrolizumab with radiotherapy and surgery improves survival in high-risk soft tissue sarcoma
1. Pembrolizumab plus radiotherapy and surgery significantly improved disease-free survival. 2. Grade 3 or higher adverse events were more common...
Radiotherapy and abiraterone improve survival in low-volume metastatic castration-sensitive prostate cancer
1. Progression-free survival improved significantly in patients with low-volume disease who received abiraterone and radiotherapy. 2. The addition of radiotherapy...
Hemodiafiltration reduces mortality compared to hemodialysis in kidney failure with dose-dependent benefits
1. Patients in the hemodiafiltration group reported a significant reduction in all-cause mortality compared to those in the hemodialysis group....
Early oral anticoagulation is non-inferior to delayed treatment in patients with ischemic stroke and atrial fibrillation
1. Early DOAC therapy within 4 days was non-inferior to delayed therapy for the composite outcome of recurrent ischemic or...
Tranexamic acid reduces life-threatening postpartum bleeding
1. Tranexamic acid significantly reduced life-threatening postpartum bleeding. 2. There were no differences in the risk of thromboembolic events. Evidence...
Cadonilimab plus chemotherapy improves survival in recurrent or metastatic cervical cancer
1. Cadonilimab plus chemotherapy significantly improved progression-free survival in patients with persistent, recurrent, or metastatic cervical cancer. 2. Common grade...
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Iscalimab shows dose-dependent improvement among patients with active Sjögren’s disease
1. Isaclimab significantly improved disease activity at 150 mg and 600 mg doses. 2. Adverse events were comparable between cohorts...
Molecular-guided therapy improves survival in unfavorable cancer of unknown primary
1. Patients in the MGT group reported a significantly greater progression-free survival than those in the standard platinum-based chemotherapy group....
Induction chemotherapy followed by chemoradiotherapy improves survival in advanced cervical cancer
1. 5-year progression-free survival was increased in the induction chemotherapy group compared to standard chemoradiotherapy. 2. Patients in the induction...
