• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • 2MM Podcast
  • Write for us
  • Contact Us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Cardiology

Troponin use for suspected coronary syndrome limited in chronic kidney disease

byKenan Celtik, MSandAimme Li, MD
August 12, 2014
in Cardiology, Chronic Disease, Emergency, Nephrology
Reading Time: 3 mins read
0
Share on FacebookShare on Twitter

1. This systematic review of the literature demonstrated weak or inconclusive evidence regarding the diagnostic accuracy of troponin I (TnI) and troponin I (TnT) in detecting acute coronary syndromes (ACS) for patients with chronic kidney disease (CKD) .

2.  Elevated troponins in patients with CKD may be associated with worse prognosis.

Evidence Rating Level: 1 (Excellent)

Study Rundown: Serum troponin is a specific marker of myocardial damage, and is important in the diagnosis of ACS. In patients with CKD, troponin levels are often persistently elevated, which can make diagnosing ACS challenging in these patients.  This systematic review described 23 peer-reviewed studies on the use of TnI and TnT in suspected ACS in patients with CKD. In this review, 14 studies reported operating characteristics (sensitivity, specificity, positive predictive value, negative predictive value) of troponins in the final diagnosis of an ACS in patients with CKD and the results were variable. Regarding the prognostic value of these assays, TnI or TnT elevation was associated with increased short-term mortality based, although this findings was based on weak evidence. Evidence was insufficient regarding the long-term prognostic value of either TnI or TnT. This study was limited by lack of blinding and moderate to high risk of bias in some studies as well as heterogeneity in the methods for ACS diagnosis and defining CKD. Moreover, there is no standardized cut off level for these assays making comparison across studies challenging. Overall, this systematic review demonstrated that elevated troponins may be useful in the diagnosis and prognosis of ACS in patients with CKD, but standardization of the assays is needed for further study.

Click to read the study, published today in the Annals of Internal Medicine

Relevant Reading: Interpreting cardiac troponin results from highly sensitive assays in patients with chronic kidney disease: acute coronary syndromes and beyond

RELATED REPORTS

SGLT2 inhibitors may delay cognitive impairment in elderly patients with heart failure

Nerandomilast slows decline in FVC in idiopathic pulmonary fibrosis

Mazdutide significantly reduces weight in adults with overweight or obesity

In-Depth [systematic review]: This systematic review of available peer-reviewed literature identified 23 studies on the use of elevated TnI and TnT in suspected ACS in patients with CKD. Six studies reported the sensitivity and specificity of troponin T ranging from 71-100% and 31-86%, respectively. Eight studies reported the sensitivity and specificity of troponin I ranging from 43-94% and 48-100%, respectively. Three studies used greater than 1 cut off level for these assays indicating a need for standardization to allow for comparison. None of the studies addressed the potential harms of false positives or the harms/benefits of treating patients based on diagnoses made with these assays. Twelve studies looked at the short and long term prognostic value of troponins, though different methods limited comparison. Low strength evidence showed that elevated TnI and TnT were associated with increased short term mortality, but insufficient evidence limited the determination of long-term outcomes for these assays.

More from this author: Rituximab not beneficial long-term in Sjorgen’s SyndromeHigh-energy shockwave therapy effective in treating shoulder calcific tendinitisTenofovir prophylaxis linked with reduced risk of herpes simplex 2 

©2012-2014 2minutemedicine.com. All rights reserved. No works may be reproduced without expressed written consent from 2minutemedicine.com. Disclaimer: We present factual information directly from peer reviewed medical journals. No post should be construed as medical advice and is not intended as such by the authors, editors, staff or by 2minutemedicine.com. PLEASE SEE A HEALTHCARE PROVIDER IN YOUR AREA IF YOU SEEK MEDICAL ADVICE OF ANY SORT.

Previous Post

Short course rifamycin matches isoniazid for treatment of tuberculosis

Next Post

Flexible sigmoidoscopy decreases colorectal cancer incidence and mortality

RelatedReports

Cardiology

SGLT2 inhibitors may delay cognitive impairment in elderly patients with heart failure

July 11, 2025
Multiple-electrode switching radiofrequency ablation may successfully treat lung tumors
Pharma

Nerandomilast slows decline in FVC in idiopathic pulmonary fibrosis

July 11, 2025
Increasing maternal BMI linked to higher risk of cerebral palsy
Cardiology

Mazdutide significantly reduces weight in adults with overweight or obesity

July 11, 2025
Biosimilar to infliximab shows equivalent safety and efficacy for treating Crohn’s disease
Chronic Disease

Oral vancomycin may be effective for pouchitis in inflammatory bowel disease

July 10, 2025
Next Post
Flexible sigmoidoscopy decreases colorectal cancer incidence and mortality

Flexible sigmoidoscopy decreases colorectal cancer incidence and mortality

Radiofrequency catheter ablation effective as first-line therapy for atrial fibrillation [RAAFT-2 trial]

Perioperative atrial fibrillation linked to increased long-term risk of stroke

Tranexamic acid during joint surgery may reduce need for blood transfusions

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • SGLT2 inhibitors may delay cognitive impairment in elderly patients with heart failure
  • Nerandomilast slows decline in FVC in idiopathic pulmonary fibrosis
  • Mazdutide significantly reduces weight in adults with overweight or obesity
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
No Result
View All Result

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.