• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • 2MM Podcast
  • Write for us
  • Contact Us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Cardiology

Cardiovascular magnetic resonance imaging phenotype with pathology-frequent late gadolinium enhancement associated with high-risk of ventricular arrhythmic and heart failure events

byZoya GomesandYuchen Dai
September 19, 2022
in Cardiology, Imaging and Intervention
Reading Time: 3 mins read
0
Share on FacebookShare on Twitter

1. In this retrospective cohort study, among 504 patients with biopsy proven sarcoidosis who underwent cardiovascular magnetic resonance imaging (CMR), the phenotype with pathology-frequent late gadolinium enhancement (LGE) was associated with a high risk of arrhythmic and heart failure events.

2. The absence of the pathology-frequent LGE phenotype was associated with a low-risk of arrhythmic events, even in the presence of LGE or abnormal left ventricular ejection fraction (LVEF).

Evidence Rating Level: 2 (Good)

Study Rundown: Cardiac sarcoidosis (CS) is an inflammatory condition characterized by impaired quality of life and high-risk of mortality. Suspected CS is frequently diagnosed and prognosticated using CMR. In studies of suspected CS investigated using CMR, cardiac damage identified as LGE has been associated with ventricular arrhythmic events. However, only a small fraction of patients with LGE have been found to experience these events. Hence, the objective of this study was to assess whether CMR phenotypes based on LVEF and LGE in patients with suspected CS are associated with adverse outcomes. A total of 504 patients with histologically proven sarcoidosis who underwent CMR for the evaluation of suspected CS between 2004 to 2020 were included in this study. The main outcomes were composite of ventricular arrhythmic and heart failure events. There were 4 distinct CMR phenotypes that were identified: normal LVEF and no LGE (n=290), abnormal LVEF and no LGE (n=53), pathology-frequent LGE (n=103), and pathology-rare LGE (n=58). The pathology-frequent LGE phenotype was found to be associated with a high risk of arrhythmic events independent of LVEF and extent of left ventricular late gadolinium enhancement (LVLGE) and was also associated with a high risk of heart failure. Both pathology-frequent LGE and LVLGE extent were independently associated with the arrhythmic endpoint, while only pathology-frequent LGE was independently associated with the heart failure endpoint. A limitation to this study was that cardiac monitoring of patients was not universally used during this study, and thus self-limiting ventricular arrhythmias could have been missed. A strength was that all patients identified for this study had a histologically-proven diagnosis of sarcoidosis.

Click to read the study in JAMA Cardiology

Relevant Reading: Presence of late gadolinium enhancement by cardiac magnetic resonance among patients with suspected cardiac sarcoidosis is associated with adverse cardiovascular prognosis

RELATED REPORTS

Artificial intelligence may assist in early detection of decreased ejection fraction on echocardiograms

#VisualAbstract: Dapagliflozin Reduced Death and Worsening Heart Failure in Transcatheter Aor-tic-Valve Implantation

AAV9.LAMP2B gene therapy shows clinical benefit in Danon disease

In-Depth [retrospective cohort]: A total of 504 patients with sarcoidosis (mean [SD] age, 54.1 years; 242 [48%] female and 262 [52%] male), who underwent CMR for the evaluation of suspected CS were included in this study. It assessed whether CMR phenotypes based on LVEF and LGE in patients with suspected CS were associated with adverse outcomes during follow-up. There were 4 distinct phenotypes identified: normal LVEF and no LGE (n=290; 57.5%), abnormal LVEF and no LGE (n=53; 10.5%), pathology-frequent LGE (n=103; 20.4%), and pathology-rare LGE (n=58; 11.5%). The pathology-frequent LGE phenotype was associated with a high risk of arrhythmic events (HR, 12.12; 95% CI, 3.62-40.57; P < .001) independent of LVEF and extent of left ventricular LGE. On Cox multivariable analyses, the same phenotype was also associated with a high risk of heart failure events (HR, 2.49; 95% CI, 1.19-5.22; P= .02). Among the patients with pathology-frequent LGE, a negative correlation was found between LVEF and left ventricular LGE extent with a Pearson correlation coefficient r of -0.58 (95% CI, -0.69 to -0.43; P < .001). At the median (IQR) follow-up period of 4.3 (2.4-6.9) years, 30 patients reached the arrhythmic end point. At the median (IQR) follow-up of 4.2 years, 60 patients reached the heart failure endpoint.

Image: PD

©2022 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: arrhythmiacardiac magnetic resonance imaging (CMR)cardiac sarcoidosisheart failureImplantable Cardioverter Defibrillator (ICD)late gadolinium enhancement (LGE)LVEF
Previous Post

Kocher Criteria differentiates pediatric septic arthritis and transient synovitis of the hip [Classics Series]

Next Post

Impact of ultrasonographic blind spots for early-stage hepatocellular carcinoma during surveillance

RelatedReports

Lisinopril and carvedilol reduce cardiotoxicity in breast cancer patients receiving trastuzumab and anthracyclines
Cardiology

Artificial intelligence may assist in early detection of decreased ejection fraction on echocardiograms

June 19, 2025
#VisualAbstract: Dapagliflozin Reduced Death and Worsening Heart Failure in Transcatheter Aor-tic-Valve Implantation
StudyGraphics

#VisualAbstract: Dapagliflozin Reduced Death and Worsening Heart Failure in Transcatheter Aor-tic-Valve Implantation

April 18, 2025
Cardiology

AAV9.LAMP2B gene therapy shows clinical benefit in Danon disease

March 14, 2025
Remote patient monitoring did not reduce heart failure readmissions: The BEAT-HF trial
Cardiology

Finerenone reduces heart failure events in patients with HFpEF

November 26, 2024
Next Post
Screening insufficient for newborns exposed to hepatitis C virus

Impact of ultrasonographic blind spots for early-stage hepatocellular carcinoma during surveillance

Dietary variety linked to greater increase in childhood BMI

Altered carbohydrate and protein intake may affect sleep quality

The Scan by 2 Minute Medicine®:  Ultra-Trail du Mont-Blanc, Taylor Swift, NBA rookie Chet Holmgren and Magic Mushrooms!

The Scan by 2 Minute Medicine®: Tennis Legends, Sausage Fingers, Alopecia Awareness Month and Starbucks Recalls!

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Tirzepatide-associated improvements in cardiometabolic risk factors linked to degree of weight loss
  • Tarlatamab in Small-Cell Lung Cancer after Platinum-Based Chemotherapy
  • 2 Minute Medicine Rewind June 23, 2025
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
No Result
View All Result

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.