Adavosertib compared with active monitoring is potentially effective against TP53/RAS-mutant metastatic colorectal cancer.

1. Patients on adavosertib had both increased progression-free survival and better tumor control, as compared to patients being actively monitored only. 2. Overall survival was...

Prostate-Specific Membrane Antigen Positron Emission Tomography can be used to detect pelvic lymph nodes...

1. For the detection of pelvic nodal metastases in men with intermediate-to high-risk prostate cancer, using the 68Ga-PSMA-11 PET scan, the sensitivity and specificity...

Non-abstinent recovery may be possible for those with Alcohol Use Disorder

1. This quantitative study found that non-abstinent alcohol use disorder recovery is sustainable up to 10 years after treatment. 2. Individuals with a profile of...

Transcatheter aortic valve replacement for bicuspid and tricuspid aortic stenosis exhibited similar outcomes for...

1. Mortality and stroke rates at 30-days and 1-year did not differ significantly between low-risk patients with bicuspid versus tricuspid aortic stenosis who underwent...

Early iBASIS–Video Interaction to Promote Positive Parenting therapy reduced autism spectrum disorder symptom severity...

1. The use of iBASIS–Video Interaction to Promote Positive Parenting (iBASIS-VIPP) led to fewer and less drastic autism spectrum disorder (ASD) symptoms in children...

Patients with a previous allergy history and women are at increased risk of rare...

1. A case series of 22 patients found that women and patients with an allergy history were more likely to have experienced an anaphylactic...

Severe aortic stenosis is associated with adverse myocardial characteristics like poor myocardial flow reserve

1. Worse myocardial flow reserve (MFR) is associated with severe aortic stenosis (AS); both MFR and aortic stenosis were independently associated with myocardial injury...

Hemodynamic-guided management of heart failure may reduce hospitalization rates

1. In the pre-COVID-19 analysis, hemodynamic monitoring reduced hospitalization and all-cause mortality rates. 2. After the COVID-19 pandemic started, hospitalization of heart failure patients was...

Probiotics not effective at reducing incidence of ventilator-associated pneumonia in critically ill patients

1. The administration of the probiotic Lactobacillus rhamnosus GG resulted in no significant difference compared to placebo in the development of ventilator-associated pneumonia in...

Third dose of ChAdOx1 nCoV-19 vaccine and prolonged second dose-intervals are both associated with...

1. An interval of 44-45 weeks between the first and second dose resulted in a four-fold increase in median antibody titers, 28-days after administration,...

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