Chronic Disease

1. Initiation of centrally acting analgesics in patients with osteoarthritis (OA) was associated with a higher long-term risk of total...

1. Physical frailty, particularly slow gait speed, was independently associated with a significantly increased risk of incident epilepsy in a...

Exercise continues to outperform pharmacologic longevity strategies Exercise remains the most consistently validated intervention for improving both lifespan and healthspan,...

1. Plasma p-tau217 was the strongest individual biomarker for predicting progression to Alzheimer's disease dementia in patients with subjective cognitive...

Metformin remains a leading candidate for pharmacologic longevity intervention Metformin continues to occupy a unique position in longevity medicine because...

1. A 4-week intradialytic pedalling exercise program was safe and well-tolerated but did not significantly improve dialysis adequacy measures.  Evidence...

1. Exposure to adverse pregnancy outcomes, particularly hypertensive disorders of pregnancy, was associated with worse cardiovascular health and early arterial...

GLP-1 receptor agonists move from weight loss into the longevity conversation GLP-1 receptor agonists are quickly shifting from niche metabolic...

1. Genotype-guided prescribing of selective serotonin reuptake inhibitors (SSRIs) may improve treatment response in children and adults with depression. Evidence...

1. Sequential and upfront treatment of metastatic colorectal cancer (mCRC) with oxaliplatin (OX)-based therapy does not lead to significantly different...