![CRISPR-mediated gene activation rescues obesity caused by haploinsufficiency [PreClinical]](https://www.2minutemedicine.com/wp-content/uploads/2019/03/CRISPR-350x250.jpg)
Single-dose CRISPR therapy reduces hereditary angioedema attacks
1. In this phase 3 randomized controlled trial, a single infusion of lonvoguran ziclumeran reduced hereditary angioedema attacks by 87%...
Once-weekly oral islatravir-lenacapavir is noninferior to daily HIV therapy
1. In this phase 3 randomized controlled trial, switching to once-weekly oral islatravir-lenacapavir maintained HIV-1 suppression as effectively as continuing...
POISE Trial: Perioperative Metoprolol Reduces MI but Increases Stroke & Mortality [Classics Series]
1. In adults undergoing noncardiac surgery, perioperative β-blocker therapy with extended-release metoprolol significantly reduced nonfatal myocardial infarction (MI) risk but...
Daily oral probiotic combination not effective at reducing antibiotic use for all-cause infection among care home residents
1. A daily probiotic combination consisting of Lactobacillus rhamnosus GG and Bifidobacterium animalis subsp lactis BB-12 did not reduce the...
Industry-sponsored anti-smoking advertisements are ineffective in stimulating smoking cessation
1. Smokers reported increased intention to quit smoking after seeing anti-smoking advertisements through television, cigarette packages, newspapers, and tobacco company...
Intraoperative dexamethasone not effective at reducing major complications or mortality in infants undergoing cardiac surgery
1. The use of intraoperative dexamethasone in infants undergoing elective cardiac surgery with cardiopulmonary bypass did not significantly reduce major...
TICO Trial: Ticagrelor monotherapy vs. extended dual anti-platelet therapy after placement of drug-eluting stents resulted in a reduction in adverse major bleeding events
1. Patients status-post placement of drug-eluting stents (DES) for acute coronary syndrome received three months of Ticagrelor and Aspirin dual-antiplatelet...
Continuous glucose monitoring improves glycemic control in adolescents and young adults with Type 1 Diabetes.
1. Patients who used continuous glucose monitoring (CGM) showed significantly reduced glycated hemoglobin (HbA1C) levels compared to those who used...
USPSTF Update: Screening adults for unhealthy drug use has moderate net benefit
1. Screening for drug abuse in adult populations by asking questions during patient appointments was found to have moderate net...
Migraines with aura linked to increased cardiovascular disease risk in women
1. In this cohort of women, those who experienced migraines with aura were associated with an increased adjusted incidence rate...
