Abelacimab reduces bleeding risk compared to rivaroxaban in atrial fibrillation
1. In this randomized controlled trial, abelacimab led to significantly lower rates of major or clinically relevant nonmajor bleeding compared...
Emergency
Intraosseous and intravenous vascular access are equally effective for ROSC following out-of-hospital cardiac arrest
1. In this randomized clinical trial, among patients who had an out-of-hospital cardiac arrest, no significant difference was found in...
Intraosseous drug administration does not improve survival in out of hospital cardiac arrest
1. In this randomized trial, intraosseous-first vascular access did not result in higher 30-day survival than intravenous-first strategies in adults...
Spironolactone ineffective for patients with preserved ejection fraction after myocardial infarction
1. In this randomized controlled trial, spironolactone did not significantly reduce death from cardiovascular causes or new or worsening heart...
Antibiotic therapy is inferior to surgery for children with uncomplicated appendicitis
1. Treatment failure was greater in the antibiotic group compared to appendicectomy group. 2. Significantly more patients in the antibiotic...
Colchicine not beneficial after acute myocardial infarction for reducing cardiovascular events
1. In this randomized controlled trial, in patients who had a myocardial infarction, a three-year treatment with colchicine was not...
Maternal obesity associated with increased risk of perinatal ischemic stroke
1. There is a dose-response relationship between maternal body mass index (BMI) and perinatal ischemic stroke (PIS) risk Evidence Rating...
Characterization of meconium-related obstruction and outcomes in term and preterm infants
Meconium-Related Obstruction and Clinical Outcomes in Term and Preterm Infants 1. Nearly 95% of cases of meconium-related obstruction (MRO) occur...
Similar patient characteristics and hospital outcomes at community and academic hospitals
1. In this retrospective cohort study of patients admitted to general medicine wards at hospitals across Ontario, Canada, community and...
Endovascular therapy improves outcomes in vertebrobasilar stroke despite increased risk of bleeding
1. Patients in the endovascular therapy group achieved greater functional outcomes at 90 days. 2. Endovascular therapy resulted in significantly...