Betibeglogene autotemcel gene therapy effective for β-thalassemia
1. Betibeglogene autotemcel (beti-cel) gene therapy resulted in sustained hemoglobin A with a T87Q amino acid substitution (HbAT87Q) in non-β0/β0...
Preclinical
Anti-psychotic medication use during pregnancy not associated with attention-deficit/hyperactivity disorder, autism spectrum disorder or small for gestational age in children
1. Children of mothers who were exposed to anti-psychotics during pregnancy, compared to those never exposed, did not have an...
Delayed antibiotic prescribing is a safe and effective for respiratory tract infections in a community setting
1. There was no difference in follow-up symptom severity between patients who received immediate or delayed antibiotics for respiratory tract...
![Fluorophores enhance visualization for image-guided surgery [PreClinical]](https://www.2minutemedicine.com/wp-content/uploads/2015/01/FISH_13_21-350x250.jpg)
Whole-genome sequencing more accurate than cytogenetic analysis in myeloid cancers
1. Whole-genome sequencing for myeloid cancers, compared to standard cytogenic analysis, was able to more effectively risk-stratify cytogenic cases. 2....
mRNA-1273 SARS-CoV-2 vaccine likely effective in nonhuman primates
1. Nonhuman primate vaccination with messenger RNA (mRNA)-1273 induced rapid neutralizing activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)....
SEP-363856 reduces symptom severity for acute exacerbation of schizophrenia
1. An oral compound, SEP-363856 was shown to significantly reduce the total score of the Positive and Negative Symptom Scale...
SARS-CoV-2 detected in respiratory, fecal, and serum specimens
1. A small number of individuals with confirmed COVID-19 were found to have viral RNA in their feces (29%) and...
Quick Take: Using Acute Optic Neuritis Trials to Assess Neuroprotective and Remyelinating Therapies in Multiple Sclerosis
1. Acute optic neuritis appears may be an appropriate condition to test neuroprotective and re-myelinating therapies after acute inflammation in...
Quick Take: Genomic characterization of metastatic breast cancers
Several late-stage cancers have been shown to acquire genomic alterations during disease evolution. In patients with breast cancer, 20% of...
Quick Take: Glucagon Receptor Antagonist–Stimulated α-Cell Proliferation Is Severely Restricted With Advanced Age
Glucagon-containing α-cells are important for regulating glucose homeostasis along with insulin-secreting β-cells. Glucagon receptor antagonists (GRAs) hold potential as antidiabetic...
