Engineered stem cells mitigate liver damage caused by radiation [PreClinical]

1. Adipose derived stem cells (ADSCs), transfected to overexpress hepatic growth factor (HGF) or to silence HGF expression, were injected into irradiated rats to...

Nanoparticle delivery of proteasomes may improve Alzheimer’s therapy [Pre Clinical]

1. Nanoparticles loaded with proteasomes, protein complexes that degrade defective proteins, were nontoxic and readily taken up by cells in vitro. 2. Delivered proteasomes promoted...

Cell-loaded scaffold implant may improve cell therapy [PreClinical]

1. A polymer scaffold modified with stimulatory molecules promoted the growth and migration of tumor-specific immune T cells in vitro and in vivo. 2. In...

Fat cell expansion protects against Staphylococcus aureus infection [PreClinical]

1. In response to infection by Staphylococcus aureus (S. aureus), dermal cell populations expanded and differentiated into adipocytes. 2. This expanding population of adipocytes produced...

Fluorophores enhance visualization for image-guided surgery [PreClinical]

1. Two near-infrared fluorophores (NIRfs), fluorescing at different wavelengths, were identified for their inherent chemical affinity for thyroid tissue. 2. The injection of both fluorophores...

Genetic mutation identified that underlies familial myelodysplastic syndrome [PreClinical]

1. Germline transmission of a mutation in ETV6 was identified in three distinct families presenting with myelodysplastic syndrome (thrombocytopenia and hematologic malignancy) inherited in...

Cancer cell mechanical behavior a target for drug treatment [PreClinical]

1. Following a chemical library screen, the compound 4-hydroxyacetophenone (4-HAP) was found to target mechanical changes in cell shape important for cell division. 2. When...

Oxytocin therapy improves social activity in autism mouse model [PreClinical]

1. Administration of oxytocin to a monogenic mouse model of autism improved social interactions 2. Oxytocin treatment during the developmental period was sufficient to improve...

Endostatin directly binds androgen receptors to treat prostate cancer [PreClinical]

1. Endostatin (ES), a drug commonly studied and applied for its inhibition of tumor blood vessel growth (termed angiogenesis), decreased proliferation of androgen-receptor (AR)...

Bevacizumab may aid tuberculosis therapy [PreClinical]

1. Tuberculosis (TB) granulomas exhibited similar properties to solid cancerous tumors, characterized as dense tissue masses with abnormal blood vessel distribution, which is thought...

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