Allopurinol does not increased mortality in gout and chronic kidney disease patients
1. In patients with gout and chronic kidney disease, the initiation of allopurinol was not associated with increased mortality. 2....
Rheumatology
Tofacitinib increases cardiovascular and cancer risk in rheumatoid arthritis
1. Patients with rheumatoid arthritis (RA) treated with tofacitinib showed a higher risk of developing major adverse cardiovascular events and...
Ianalumab shows a dose-related improvement in disease activity in Sjögren’s syndrome
1. There was a dose-related decrease in disease activity from baseline to 24-weeks for patients on ianalumab compared to placebo....
Secondary Antibiotic Prophylaxis Reduces Rheumatic Heart Disease Progression
1. In patients with latent rheumatic heart disease, secondary antibiotic prophylaxis reduced the risk of rheumatic heart disease progression. 2....
Therapeutic aquatic exercise is superior at improving disability and severity of low back pain compared to physical therapy
1. This single-blind, randomized controlled trial found that disability and severity of low back pain significantly improved in the aquatic...
Tofacitinib reduces the rate of flare-ups in patients with polyarticular juvenile idiopathic arthritis
1. Patients in the tofacitinib group reported significantly fewer flare-ups (29%) compared to placebo (53%) by week 44. 2. The...
Dual therapy with infliximab and IVIG in children with multi-system inflammatory syndrome
1. In a single center retrospective cohort study of children with multi-system inflammatory syndrome (MIS-C), children treated with IVIG and...
Use of sodium-glucose transport protein 2 inhibitors associated with lowered incidence of gout in patients with type 2 diabetes
1. The use of sodium-glucose transport protein 2 inhibitors in patients with type 2 diabetes was associated with a lowered...
Belimumab after rituximab reduces risk for severe flare in systemic lupus erythematosus
1. Belimumab combined with rituximab was shown to significantly reduce IgG anti-dsDNA antibody levels in patients with systemic lupus erythematosus....
Platelet-rich plasma injections did not significantly improve ankle symptoms compared to placebo in patients with ankle osteoarthritis
1. This trial included 100 patients and took place over a 26-week period, ultimately concluding that platelet-rich plasma (PRP) injections...