The RECIST 1.1 trial: Measuring tumor burden to assess response to therapy [Classics Series]
The following study summary is an excerpt from the book 2 Minute Medicine’s The Classics in Radiology: Summaries of Clinically Relevant...
Hematology/Oncology Classics
Landmark studies in hematology/oncology, organized using 2 Minute Medicine’s The Classics table of contents.
Anastrazole superior to tamoxifen for breast cancer treatment [Classics Series]
1. Postmenopausal women with advanced breast cancer randomized to anastrazole as first-line therapy experienced an increase in time to progression...
![Adverse pregnancy outcomes associated with thrombophilias [Classics Series]](https://www.2minutemedicine.com/wp-content/uploads/2015/07/Classics-2-Minute-Medicine-e1436017941513-350x250.png)
The SOME trial: Screening for occult malignancy in unprovoked venous thromboembolism [Classics Series]
1. Patients with a first unprovoked venous thromboembolism were randomized to either limited-screening for occult malignancy or limited-screening plus computed...
The AMPLIFY trial: Apixaban for treatment of venous thromboembolism [Classics Series]
1. Apixaban was found to be non-inferior to conventional therapy (i.e., enoxaparin followed by warfarin) in the treatment of acute...
Vena caval filters in pulmonary embolism prophylaxis [Classics Series]
Image: PD 1. Permanent vena caval filter placement in addition to anticoagulant therapy helps prevent short-term occurrence of pulmonary embolism...
Dexamethasone effective as initial therapy for immune thrombocytopenic purpura [Classics Series]
1. Of 125 patients with newly diagnosed immune thrombocytopenic purpura, 106 (85%) had an initial response to high-dose dexamethasone therapy...
Finasteride significantly reduces incidence of prostate cancer [Classics Series]
1. Finasteride therapy was found to significantly reduce the incidence of prostate cancer compared to placebo. 2. Patients treated with...
The ATLAS trial: Duration of adjuvant tamoxifen in ER-positive breast cancer [Classics Series]
Image: PD 1. Among women with early ER-positive breast cancer, continuing adjuvant tamoxifen for 10 years versus stopping at 5...
The PLCO trial 1: PSA and digital rectal examination in prostate cancer screening [Classics Series]
Image: PD 1. Subjects undergoing annual prostate-specific antigen (PSA) testing for 6 years and annual digital rectal examination (DRE) for...
The PLCO trial 2: Flexible sigmoidoscopy in colon cancer screening [Classics Series]
Image: PD 1. Screening with flexible sigmoidoscopy is associated with a significant decrease in colon cancer incidence in the distal...
