The Classics

Physician-written reports of landmark studies in medicine

The ROMICAT 2 trial: Coronary computed tomographic angiography shortens hospital stays for acute chest pain...

The following study summary is an excerpt from the book 2 Minute Medicine’s The Classics in Radiology: Summaries of Clinically Relevant & Recent Landmark Studies,...

Cervical length indicates risk of preterm delivery [Classics Series]

1. Transvaginal cervical length measured at 24 and 28 weeks gestation was inversely associated with risk of spontaneous preterm delivery in a dose-dependent manner.Original...

The RECIST 1.1 trial: Measuring tumor burden to assess response to therapy [Classics Series]

The following study summary is an excerpt from the book 2 Minute Medicine’s The Classics in Radiology: Summaries of Clinically Relevant & Recent Landmark Studies,...

LUNG-RADS criteria increases positive predictive value for lung cancer detection in high-risk patients [Classics Series]

The following study summary is an excerpt from the book 2 Minute Medicine’s The Classics in Radiology: Summaries of Clinically Relevant & Recent Landmark Studies,...

The ROMICAT 1 trial: Coronary computed tomographic angiography highly sensitive for acute coronary syndrome in...

The following study summary is an excerpt from the book 2 Minute Medicine’s The Classics in Radiology: Summaries of Clinically Relevant & Recent Landmark Studies,...

Fleischner Society Guidelines, 2017 Update: Consolidated follow-up recommendations for incidental solid and subsolid pulmonary nodules...

The following study summary is an excerpt from the book 2 Minute Medicine's The Classics in Radiology: Summaries of Clinically Relevant & Recent Landmark Studies,...
Classics Series, Landmark Trials in Medicine

Anastrazole superior to tamoxifen for breast cancer treatment [Classics Series]

1. Postmenopausal women with advanced breast cancer randomized to anastrazole as first-line therapy experienced an increase in time to progression and a more favorable...

The PARADIGM-HF trial: Valsartan-neprilysin inhibitor vs. enalapril in patients with heart failure [Classic Series]

1. LCZ696, a combination of valsartan with a neprilysin inhibitor, significantly reduced the risk of death from cardiovascular causes and hospitalization due to heart...

The DOSE trial: Loop diuretic strategies in acute decompensated heart failure [Classics Series]

1. The use of loop diuretics in acute decompensated heart failure is commonplace, but clinical practice varies widely with regards to the dosage and...

The AREDS2: No benefit from additional carotenoid and omega-3-fatty acid supplementation to original AREDS...

1. There was no added benefit observed with adding lutein and zeaxanthin, omega-3-fatty acids (DHA and EPA), or the combination to the original AREDS...
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