The Classics

Physician-written reports of landmark studies in medicine

The EVS: Vitrectomy results in better visual outcomes for light-perception patients [Classics Series]

1. In patients with endophthalmitis after recent lens implantation, immediate vitrectomy significantly improved visual outcomes for patients presenting with light-perception visual acuity compared to...

The TNT trial: Intensive statin therapy in coronary heart disease [Classics Series]

1. In patients with stable coronary heart disease (CHD), high-dose atorvastatin significantly reduced the risk of major cardiovascular events when compared to low-dose.2. Patients...

The ONTT: Intravenous steroids lead to faster visual recovery in optic neuritis [Classics Series]

1. In patients with first presentation of optic neuritis, treatment with intravenous methylprednisolone followed by oral prednisone resulted in faster visual recovery when compared...

The AREDS1: Zinc and antioxidant supplementation reduce progression of AMD in high-risk patients [The...

1. In patients with advanced age-related macular degeneration (AMD) in one eye only or intermediate AMD in either eye, zinc and antioxidant supplementation reduced...

The FREEDOM trial: Coronary bypass graft vs. PCI in diabetic patients [Classics Series]

1. In patients with diabetes and multivessel disease, coronary artery bypass grafting (CABG) was shown to be superior to percutaneous coronary intervention (PCI) with...

The SHIFT: Ivabradine in congestive heart failure [Classics Series]

1. In patients with congestive heart failure (CHF) and baseline heart rate >70 bpm, ivabradine significantly reduced the risk of heart failure hospitalization and...

The LRC-CPPT 1: Cholestyramine and coronary heart disease [Classics Series]

1. In the 1970s, observational data suggested a direct link between serum cholesterol levels and the risk of coronary heart disease (CHD).2. This trial...

The ICAP trial: Colchicine in acute pericarditis [Classics Series]

1. Colchicine has been commonly used in the treatment of inflammatory conditions, including gout and serositis.2. This study demonstrated that colchicine, in addition to...

The AVERROES trial: Apixaban vs aspirin in atrial fibrillation [Classics Series]

1. In patients with atrial fibrillation who were unable to receive warfarin for any reason, the use of apixaban reduced the risk of stroke...

The SCD-HeFT: ICD vs. amiodarone for congestive heart failure [Classics Series]

1. In patients with congestive heart failure (CHF) and reduced ejection fraction, mortality was significantly lower in patients who received an implantable cardioverter-defibrillator (ICD)...
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