The Classics

Physician-written reports of landmark studies in medicine

The HOT trial: Diastolic blood pressure targets in hypertension [Classics Series]

1. In hypertensive patients, there were no significant differences between different diastolic blood pressure (dBP) targets (≤90 mmHg,≤85 mmHg,≤80 mmHg) with regards to the...

The SPRINT: Intensive vs. standard blood pressure control [Classics Series]

1. In patients with hypertension and elevated cardiovascular risk, treating to a target systolic blood pressure of 120 mmHg significantly reduced the risk of...

The BHAT: Propranolol after acute myocardial infarction [Classics Series]

1. Beta-blockers were commonly used in the treatment of coronary artery disease in the 1980s, though prior studies were inconclusive due to limitations in...

The REMATCH trial: Left ventricular assist devices reduce mortality in heart failure [Classics Series]

1. In patients with end-stage heart failure on optimal medical therapy, treatment with a left ventricular assist device (LVAD) significantly reduced the risk of...

The VALIANT trial: Valsartan vs. captopril in patients with acute myocardial infarction and heart...

1. In patients with acute myocardial infarction and heart failure/evidence of left ventricular dysfunction, patients treated with valsartan and captopril experienced similar all-cause mortality.2....

The POISE 2 trial: Aspirin increases risk of major bleeding after noncardiac surgery [Classic...

1. After noncardiac surgeries, patients treated with aspirin had significantly increased risk of major bleeding compared to those taking placebo.2. There was no significant...

Antenatal steroids for fetal lung maturity [Classics Series]

1. Respiratory distress syndrome (RDS) and perinatal mortality were significantly less common among preterm infants whose mothers received betamethasone prior to delivery.Original Date...

V-HeFT II: Enalapril reduces mortality in heart failure when compared to hydralazine and isosorbide...

1. In patients with heart failure, patients treated with enalapril experienced significantly lower mortality at 2-years compared to patients on hydralazine and isosorbide dinitrate.2....

The MADIT-CRT trial: Cardiac resynchronization therapy in heart failure [Classics Series]

1. In patients with heart failure, reduced left ventricular ejection fraction, and prolonged QRS>130 ms, treatment with cardiac resynchronization therapy (CRT), in addition to...

Periconceptional folic acid for prevention of neural tube defects [Classics Series]

1. Among women seeking pregnancy, those randomized to folic acid supplementation were significantly less likely to develop a fetus with a neural tube defect.Original...
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