Donepezil and vitamin E in Alzheimer’s disease [Classics Series]
Image: PD 1. High-dose vitamin E supplementation does not slow down progression to Alzheimer’s disease 2. Donepezil, a cholinesterase inhibitor,...
Psychiatry Classics
Physician-written reports of landmark psychiatry studies
Symptom-triggered benzodiazepine treatment for alcohol withdrawal [Classics Series]
Image: PD 1. For patients withdrawing from alcohol, a symptom-triggered pharmacologic therapy may decrease detoxification time without compromising the safety...
The STAR*D trials I: Medication augmentation for depression [Classics Series]
1. In patients who have not experienced remission of depression despite vigorous treatment with an SSRI, augmentation of treatment by...
The CATIE trial: High rates of medication discontinuation in schizophrenic patients [Classics Series]
1. Approximately 74% of schizophrenic patients discontinued their medications before 18 months, with the median being 6 months. 2. Olanzapine...
The STAR*D trials II: Switching antidepressants [Classics Series]
1. In cases where citalopram fails or cannot be tolerated, approximately 1 in 4 patients will experience remission of their...