• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Obstetrics

Decreased breast cancer recurrence and mortality following post-mastectomy radiotherapy

byRehan SaiyedandAllen Ho, MD
March 29, 2014
in Obstetrics, Oncology, Surgery
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

Image: PD 

1. Radiotherapy administered after mastectomy and axillary dissection decreased 10-year recurrence and 20-year mortality in women with node-positive breast cancer. 

2. No reduction in recurrence and mortality was shown for women with node-negative breast cancer who were given radiotherapy following mastectomy and axillary dissection. 

Evidence Rating Level: 1 (Excellent) 

Study Rundown: Radiotherapy has been used in clinical practice to treat any remaining tumor foci following mastectomy and axillary dissection in women with node positive breast cancer. Current guidelines recommend adjuvant radiotherapy after mastectomy for women with four or more positive axillary lymph nodes. However, no previous analysis has clearly shown the utility of radiotherapy for women with one to three positive nodes. This meta-analysis suggests a benefit of radiotherapy in this population, as evidenced by decreased rates of recurrence and breast cancer mortality in women with one to three positive lymph nodes. A limitation of this study is how far in the past the women were treated. Patients who received radiotherapy between the years of 1964 to 1980 were included. Advances made in the effectiveness of more non-invasive treatments, particularly, targeted systemic therapies, likely renders patients today at a lower overall risk for recurrence and mortality. As a result, it becomes difficult to generalize these results for today’s population.

Click to read the study in Lancet

Relevant Reading:Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials

RELATED REPORTS

Screening with digital breast tomosynthesis vs mammography associated with significantly lower risk of advanced breast cancer among women with extremely dense breasts at high risk of breast cancer

Pelvic lymph node radiotherapy and androgen deprivation therapy augment progression-free status following prostatectomy

#VisualAbstract: Adjuvant capecitabine improves long-term survival in early breast cancer

In-Depth [meta-analysis]: Over 8000 women from 22 randomized clinical trials of adjuvant radiotherapy versus no radiotherapy following mastectomy  with axillary dissection were included in the analysis. For women with no positive nodes after axillary dissection, there was no change in rates of local recurrence, overall recurrence, or breast cancer mortality. Radiotherapy did reduce the local recurrence (p<.00001), overall recurrence (RR = 0.68, 95% CI 0.57-0.82, p<.0001) and breast cancer mortality (RR = 0.80, 95% CI 0.67-0.95, p=.01) in women with one to three positive nodes. 86% of these women were concurrently on systemic therapy, and significant reductions in all three parameters were maintained with radiotherapy. Reductions in local recurrence (p<.00001), overall recurrence (RR = 0.79, 95% CI 0.69-0.90, p<.001), and breast cancer mortality (RR = 0.87, 95% CI 0.77-0.99, p<.05) were also found in women shown to have four or more positive lymph nodes.

©2012-2014 2minutemedicine.com. All rights reserved. No works may be reproduced without expressed written consent from 2minutemedicine.com. Disclaimer: We present factual information directly from peer reviewed medical journals. No post should be construed as medical advice and is not intended as such by the authors, editors, staff or by 2minutemedicine.com. PLEASE SEE A HEALTHCARE PROVIDER IN YOUR AREA IF YOU SEEK MEDICAL ADVICE OF ANY SORT.  

Tags: Breast Cancerradiotherapy
Previous Post

Minimal association between economic growth and childhood undernutrition for world’s poorest

Next Post

Various factors impact quality of life in patients with chronic pruritus

RelatedReports

2 Minute Medicine Rewind March 4, 2019
Chronic Disease

Screening with digital breast tomosynthesis vs mammography associated with significantly lower risk of advanced breast cancer among women with extremely dense breasts at high risk of breast cancer

June 16, 2022
Patient-reported outcomes differ significantly based on treatment in prostate cancer: The ProtecT trial
Chronic Disease

Pelvic lymph node radiotherapy and androgen deprivation therapy augment progression-free status following prostatectomy

May 24, 2022
#VisualAbstract: Adjuvant capecitabine improves long-term survival in early breast cancer
StudyGraphics

#VisualAbstract: Adjuvant capecitabine improves long-term survival in early breast cancer

May 18, 2022
Wellness

Several factors influence health programs conducted in the African American Church

May 18, 2022
Next Post
Various factors impact quality of life in patients with chronic pruritus

Various factors impact quality of life in patients with chronic pruritus

Colchicine safe and effective for recurrent pericarditis [CORP-2 trial]

Colchicine safe and effective for recurrent pericarditis [CORP-2 trial]

Adolescents’ muscle strength associated with lower cardiometabolic risk

Adolescents’ muscle strength associated with lower cardiometabolic risk

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Relugolix combination therapy is efficacious for endometriosis-associated pain
  • Age-based products and longer interdose intervals may reduce the risk of cardiac disease following COVID-19 mRNA vaccination
  • OPTN and UNOS update policy regarding hepatocellular carcinoma [Classics Series]
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.