• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Chronic Disease

Do higher doses help? Infant bone health similar despite varying Vitamin D doses

bys25qthea
September 15, 2013
in Chronic Disease, Pediatrics
Reading Time: 3 mins read
0
Share on FacebookShare on Twitter

Image: PD

1. There was no difference in bone mineral content, as measured by dual-energy absorptiometry scans, in any of the different Vitamin D dosage groups, including the standard 400IU supplementation group.

2. It remains unknown if non-bone health benefits may arise from Vitamin D supplementation in excess of 400IU daily. 

Evidence Rating Level: 2 (Good) 

Study Rundown: Vitamin D supplementation is required in breastfed infants, as necessary amounts are not provided in breastmilk. For this reason, 400 IU supplementation is recommended daily, as it has been demonstrated to prevent rickets. There has been some debate as to the optimal serum concentrations of 25-OH-Vitamin D.  While the authors of this study intended to determine dosage of Vitamin D supplementation to maintain 25-OH-Vitamin D levels > 75nmol/L, the only treatment group to achieve this (1600IU/d) had levels so elevated that there was concern for hypercalcemia. Perhaps more importantly, the study affirms that 400 IU/d led to comparable measures of bone health in comparison to higher levels of supplementation using measures such as as measured by dual-energy absorptiometry (DEXA) scans.

The strengths of this study include its analysis of variables which may have an effect on plasma 25-OH-Vitamin D levels, including the potential for differential sunlight exposure, nutrition other than breastfeeding, parental demographics and compliance. Among limitations, the population being studied was narrow and did not include preterm or otherwise ill infants, or those who may be darker skinned and require more Vitamin D supplementation. Given that standard supplementation provide equal levels of bone health compared to increased supplementation, further research will be crucial in determining if there are any other benefits that would arise from further Vitamin D supplementation.

Click to read the study, published today in JAMA

RELATED REPORTS

Higher body mass index may be associated with altered vitamin D levels and metabolism

2 Minute Medicine Rewind January 23, 2023

Vitamin D supplementation in children increases serum levels but may not impact growth

Click to read an accompanying editorial, published today in JAMA

Relevant Reading: Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline

In-Depth [prospective, double-blind, randomized]: 132 one month old infants from a single center in Montreal, Canada were enrolled in the study. These infants were otherwise healthy, at term, and breastfed. They were randomized for Vitamin D supplementation in dosages of 400 IU/d, which is the current recommended dose, 800 IU/d, 1200 IU/d, or 1600 IU/d. The primary outcome measure was a concentration of 25-OH-Vitamin D of 75 nmol/L among >97.5% of sample at 3 months. The only group to successfully reach this goal was the 1600 IU/d group. However, this group was associated with plasma 25-OH-Vitamin D concentrations that were so high (>250nmol/L) that it required discontinuation of this treatment group. Neither bone mineral density nor growth differed among any of the supplementation treatment groups.

By Anne Marie Walters and Rif Rahman

© 2013 2minutemedicine.com. All rights reserved. No works may be reproduced without written consent from 2minutemedicine.com. Disclaimer: We present factual information directly from peer reviewed medical journals. No post should be construed as medical advice and is not intended as such by the authors or by 2minutemedicine.com. PLEASE SEE A HEALTHCARE PROVIDER IN YOUR AREA IF YOU SEEK MEDICAL ADVICE OF ANY SORT. Content is produced in accordance with fair use copyrights solely and strictly for the purpose of teaching, news and criticism. No benefit, monetary or otherwise, is realized by any participants or the owner of this domain. 

Tags: bone healthvitamin d
Previous Post

Procalcitonin levels linked with acute pyelonephritis

Next Post

Reduced HPV vaccine doses may be adequate

RelatedReports

Sleep duration inversely related to childhood type 2 diabetes risk makers
Chronic Disease

Higher body mass index may be associated with altered vitamin D levels and metabolism

January 27, 2023
Many new pediatric asthma cases attributable to obesity
Weekly Rewinds

2 Minute Medicine Rewind January 23, 2023

January 23, 2023
Adolescent mothers in protective care more likely to have their children placed in care
Chronic Disease

Vitamin D supplementation in children increases serum levels but may not impact growth

December 16, 2022
#VisualAbstract: Double sequential external defibrillation and vector-change defibrillation improve outcomes in patients with refractory ventricular fibrillation
StudyGraphics

#VisualAbstract: Vitamin D supplementation is not preventative for statin-associated muscle symptoms or statin discontinuation

December 8, 2022
Next Post
Reduced HPV vaccine doses may be adequate

Reduced HPV vaccine doses may be adequate

Genetic mutations may protect infants born to drug-using mothers

Genetic mutations may protect infants born to drug-using mothers

Subarachnoid hemorrhage patients receive significant radiation exposure

Subarachnoid hemorrhage patients receive significant radiation exposure

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • BNT162b2 booster is safe and reduces COVID-19 transmission in older adults
  • Bisphosphonates, denosumab, abaloparatide, teriparatide, and romosozumab reduce postmenopausal fracture risk
  • Epstein-Barr viral load monitoring reduces risk of post-liver transplant lymphoproliferative disease
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

Want more physician-written
medical news?

Join over 10 million yearly readers and numerous companies. For healthcare professionals
and the public.

Subscribe for free today!

Subscription options