• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Surgery

Glutamine and antioxidant supplementation provide no benefit for critically-ill patients

bys25qthea
April 17, 2013
in Surgery
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

Image: PD

1. Glutamine supplementation in intensive care unit (ICU) patients increases mortality while antioxidant supplementation does not provide any additional benefit. 

2. Elevated urea levels were observed more frequently in patients receiving glutamine. 

Evidence Rating Level: 1 (Excellent) 

Study Rundown: Critically ill patients are a population with known oxidative stress. Previous meta-analyses of smaller randomized control trials (RCT) demonstrated reduced mortality in critically ill patients who received glutamine and antioxidants in the intensive care unit (ICU). This study was the first large-scale international multi-center RCT to demonstrate that glutamine increases mortality and antioxidants provide no significant benefit in ICU patients. The randomized groups in this study were homogenous and the results can be generalized to most patients in ICU with multi-organ failure.

This study was unique from prior studies in that critically ill patients with multiorgan failure were accepted into the study, and were also receiving the highest possible dose of glutamine. These differences may have accounted for the statistical differences observed and might explain the dissonance with prior findings. Future studies might focus on elucidating the mechanism of action of glutamine in critically-ill patients.

Click to read the study, published online today in NEJM

RELATED REPORTS

Enteral glutamine does not reduce the time to discharge for severe burns

#VisualAbstract: Intravenous vitamin C increases mortality and organ dysfunction in sepsis patients

Captopril mitigates radiation-induced lung fibrosis in rats

In-Depth [randomized, multicenter, international study]: This study included 1,223 intensive care unit (ICU) patients with multi-organ failure from 40 different ICUs in Canada, the United States and Europe. Patients were randomized into one of four groups – placebo, glutamine, antioxidants, glutamine plus antioxidants. The primary outcome was 28-day mortality, which was 32.6% v. 25.3% in the glutamine-only v. placebo (p=0.05) and 29.0% v. 25.3% in the antioxidant v. placebo (p=0.48). The overall adjusted odds ratio with glutamine was 1.28 (p=0.05) and 1.09 (p=0.48) with antioxidants. Elevated urea levels (>50 mmol/L) were observed in 13.4% and 4.0% in the glutamine v. no glutamine groups (p<0.001).

By Jonathan Liu and Mitalee Patil

More from this author: PFO Closure equivalent to medical management in prevention of recurrent stroke, Combo antifungal therapy most effective treatment for cryptococcal meningitis,  Rhinovirus, genes may interact to increase risk of childhood asthma, Functional MRI map for physical pain identified

© 2013 2minutemedicine.com. All rights reserved. No works may be reproduced without written consent from 2minutemedicine.com. Disclaimer: We present factual information directly from peer reviewed medical journals. No post should be construed as medical advice and is not intended as such by the authors or by 2minutemedicine.com. PLEASE SEE A HEALTHCARE PROVIDER IN YOUR AREA IF YOU SEEK MEDICAL ADVICE OF ANY SORT. Content is produced in accordance with fair use copyrights solely and strictly for the purpose of teaching, news and criticism. No benefit, monetary or otherwise, is realized by any participants or the owner of this domain. 

Tags: antioxidantglutamine
Previous Post

Lifestyle modifications vary based on socioeconomic status in cardiovascular patients (PURE Study)

Next Post

Increased inflammatory markers found in nonsurviving pediatric burn patients

RelatedReports

Patient transfers to trauma centers often unnecessary
Dermatology

Enteral glutamine does not reduce the time to discharge for severe burns

September 16, 2022
#VisualAbstract: Intravenous vitamin C increases mortality and organ dysfunction in sepsis patients
StudyGraphics

#VisualAbstract: Intravenous vitamin C increases mortality and organ dysfunction in sepsis patients

July 7, 2022
Ambrisentan found ineffective against idiopathic pulmonary fibrosis
Oncology

Captopril mitigates radiation-induced lung fibrosis in rats

May 30, 2014
Next Post
Increased inflammatory markers found in nonsurviving pediatric burn patients

Increased inflammatory markers found in nonsurviving pediatric burn patients

Silent myocardial infarctions more common than previously assumed

Silent myocardial infarctions more common than previously assumed

Contraband tobacco leads to reduced smoking cessation

Contraband tobacco leads to reduced smoking cessation

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Specific histopathologic renal lesions may be associated with increased risk of cardiovascular disease
  • Symptom and viral relapse more common in COVID-19 patients without antiviral treatment
  • The Scan by 2 Minute Medicine®: Endometriosis Awareness Month, OnlineMedEd Charges, Canadian Grocery Store Controversy, BetterHelp’s Privacy Concerns
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

Want more physician-written
medical news?

Join over 10 million yearly readers and numerous companies. For healthcare professionals
and the public.

Subscribe for free today!

Subscription options