• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Obstetrics

History of recurrent spontaneous abortions linked to increased risk of premature mortality

byJessie WillisandTeddy Guo
April 12, 2021
in Obstetrics
Reading Time: 3 mins read
0
Share on FacebookShare on Twitter

1. Spontaneous abortion could potentially serve as a marker for future health risk in women, particularly death from cardiovascular disease.

2. Association of risk is particularly strong with women who experience three or more recurrent spontaneous abortions and those reporting spontaneous abortions occurring before age 24.

Evidence Rating Level: 2 (Good)

Study Rundown: Pregnancy is thought to be the ultimate stress test on the body, as a woman’s body must work overtime to support the needs of the fetus. Underlying risk factors for premature mortality, such as poor cardiovascular health or gestational diabetes, may arise for the first-time during pregnancy and return later in life. Additionally, spontaneous abortions are a common adverse outcome of pregnancy that may have implications for maternal health. Using the Nurses’ Health Study II (1993), this publication compares the reported reproductive history of spontaneous abortions and risk of premature death of women throughout 24 years of follow-up. Women who have had self-reported spontaneous abortions were seen to be at a higher risk for premature death, notability death from cardiovascular disease. This association strengthens for women who have had multiple spontaneous abortions or those would had spontaneous abortions before age 24. Strengths of this study over similar include the large sample size, thorough follow-up, prospective nature, and ability to adjust and modify for many variables, such as lifestyle, reproductive, and health factors. As an RCT is not possible with spontaneous abortions, this study cannot demonstrate causality; however, causality is not required to rationalize that spontaneous abortion is a marker, rather than a cause, of premature death. This study further supports that pregnancy is a physiological stress test and reproductive events can indicate health later in a woman’s life.

Click to read the study in the BMJ

Relevant Reading: Spontaneous loss of early pregnancy and risk of ischaemic heart disease in later life: retrospective cohort study

In-Depth [prospective cohort]: The Nurses’ Health Study II is a currently ongoing prospective cohort study of 116 429 nurses (aged 25-42) with continuous follow-up spanning three decades. Inclusion criteria was based on non-zero gravida (n=101 681) and exclusion criteria included death before 1993 and missing history data. History was taken through questionnaires every two years on pregnancies, spontaneous and induced abortions. Cause of death was determined by autopsy reports, medical records, and death certificates. Many other variables were reported: gestational diabetes and hypertensive disorders of pregnancy were self-reported; body weight, height, race, and ethnicity were collected at baseline in follow-ups; family history and social history were updated every two to four years. Overall, there were 2936 premature deaths (1346 from cancer and 269 from cardiovascular disease) in the study cohort. Cause-specific analysis showed spontaneous abortion was not associated with death from cancer (hazard ratio 1.08, 95% CI 0.94 to 1.24), but was associated with greater risk of death from cardiovascular disease (1.48, 95% CI 1.09 to 1.99). The final multivariable adjusted hazard ratios for all cause premature death were 1.59 (95% CI 1.17 to 2.15) for three or more spontaneous abortions, 1.23 (95% CI 1.00 to 1.50) for two spontaneous abortions, and 1.16 (95% CI 1.05 to 1.28) for one spontaneous abortion. Additionally, multivariable adjusted hazard ratio was 1.32 (95% CI 1.14 to 1.53) for a first spontaneous abortion occurring in women aged 23 or younger relative to no spontaneous abortion. Compared to gravid women who never had a spontaneous abortion, hazard ratios for premature mortality from cardiovascular disease were 1.59 (95% CI 1.15 to 2.20) for women who had a spontaneous abortion and 1.06 (95% CI 0.70 to 1.62) for women who had an induced abortion, but no spontaneous abortion.

RELATED REPORTS

Presence of second midwife during the second active stage of labour reduces the risk of severe perineal trauma

2 Minute Medicine Rewind March 28th, 2022

The effect of inter-pregnancy interval on stillbirth in urban South Ethiopia

Image: PD

©2020 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: abortionmaternal healthmaternal morbiditymaternal mortalityobstetricsrecurrent spontaneous abortionsspontaneous abortion
Previous Post

#VisualAbstract Rituximab plus high-dose chemotherapy (MegaCHOEP) show similar long-term efficacy to conventional chemotherapy (CHOEP-14) in young, high-risk patients with aggressive B-cell lymphoma

Next Post

2 Minute Medicine Rewind April 12, 2021

RelatedReports

Women electing abortion more likely to be victims of domestic violence
Chronic Disease

Presence of second midwife during the second active stage of labour reduces the risk of severe perineal trauma

April 7, 2022
Poverty, preterm birth demonstrate additive effect on cognition
Chronic Disease

2 Minute Medicine Rewind March 28th, 2022

March 28, 2022
Paternal factors associated with short interpregnancy interval
Chronic Disease

The effect of inter-pregnancy interval on stillbirth in urban South Ethiopia

January 24, 2022
Quick Take: Functional Outcome of Intravenous Thrombolysis in Patients With Lacunar Infarcts in the WAKE-UP Trial
Weekly Rewinds

2 Minute Medicine Rewind January 24, 2022

January 31, 2022
Next Post
Image-guided percutaneous drainage of pericardial effusions is safe and effective

2 Minute Medicine Rewind April 12, 2021

Psychological impact of COVID-19 on health care workers in Singapore

Mood disorders and outcomes of COVID-19 hospitalizations

Blood type correlates with egg reserve in infertile women

Sutimlimab improved hemoglobin and patient symptoms in cold agglutinin disease

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

Get 2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Wellness Check: Mental Health
  • #VisualAbstract: Addition of elotuzumab to lenalidomide and dexamethasone did not significantly improve survival outcomes in newly diagnosed, transplant-ineligible multiple myeloma
  • #VisualAbstract: Pretreatment with radiotherapy and two cycles of concurrent cisplatin may reduce toxicity in locally advanced nasopharyngeal carcinoma
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.