Tag: obstetrics

1. Dolutegravir-based antiretroviral therapy regimens effectively suppressed maternal viral load during pregnancy, supporting their use to prevent vertical transmission. 2. Dolutegravir, emtricitabine, and tenofovir alafenamide fumarate carried relatively low risk of adverse fetal outcomes. Evidence Rating Level: 1 (Excellent) Study Rundown: Initiation of antiretroviral therapy (ART) for pregnant women infected with HIV-1...

1. Spontaneous abortion could potentially serve as a marker for future health risk in women, particularly death from cardiovascular disease. 2. Association of risk is particularly strong with women who experience three or more recurrent spontaneous abortions and those reporting spontaneous abortions occurring before age 24. Evidence Rating Level: 2...

1. Systematic review of RCTs demonstrates reduced rate of early preterm birth (<34 weeks) for high-risk (previous spontaneous preterm birth, short cervix) singleton pregnancies with vaginal progesterone and intramuscular 17-hydroxyprogesterone caproate (17-OHPC). 2. Efficacy of vaginal progesterone and 17-OHPC may be more effective for women with short cervices.  Evidence Rating Level:...

1. Among preterm and extremely low birth weight neonates, the co-exposure to antenatal steroids and postnatal indomethacin was associated with an increased risk of spontaneous intestinal perforation. Evidence Level Rating: 2 (Good) Both antenatal steroids (ANS) and postnatal indomethacin (PI) are utilized in neonatology to reduce the morbidity and mortality associated...

1. Children of mothers who supplemented with folic acid (FA) during the second and third trimesters demonstrated greater processing speed at 11 years of age. 2. FA supplementation in later pregnancy resulted in stronger verbal comprehension skills among females. Evidence Rating Level: 2 (Good) Folic acid (FA) has been shown to prevent...

Association of intensive vs standard blood pressure control with magnetic resonance imaging biomarkers of Alzheimer's Disease 1. Intensive treatment of blood pressure resulted in small but statistically significant greater decline in hippocampal volume compared to standard treatment. 2. No significant differences between treatment groups in other Alzheimer’s disease biomarkers. Evidence Rating Level:...

1. In Washington State, pregnant patients were found to be at a higher risk of SARS-CoV-2 infection. 2. Results were more pronounced if patients belonged to a non-white racial or ethnic group or received their care in a language other than English. Evidence Level Rating: 2 (Good) As the COVID-19 pandemic continues...

1. The use of opioid medications during the first trimester is not significantly associated with greater risk of congenital malformations. 2. Following adjustments, opioid use during the first trimester was associated with a greater relative risk of oral clefts. Evidence Rating Level: 2 (Good) Pregnant women experience pain to varying degrees, yet...

1. Pregnant women using biologic treatments for psoriasis, both before and during pregnancy, were found to have similar pregnancy outcomes as the general American population. Evidence Rating Level: 2 (Good) Psoriasis is a chronic inflammatory skin disease affecting 7 million adults in the United States. It has been hypothesized that the...

1. Increased breastfeeding satisfaction was 47% higher among mothers who were negative for postpartum depression compared to those who were positive for postpartum depression. Evidence Rating Level: 3 (Average) Breastfeeding and maternal health provide innumerable health benefits to newborn children. There are also many factors that can negatively impact maternal health...