• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • 2MM Podcast
  • Write for us
  • Contact Us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Pediatrics

Hypertonic saline may be effective in bronchiolitis

byJames GrayandCordelia Ross
September 28, 2015
in Pediatrics, Pulmonology
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

1. The use of hypertonic saline (HS) in bronchiolitis was associated with lower risk of hospital admission, shorter length of stay (LOS), and improved clinical severity scores.

2. The use of HS appears to be safe, with very few minor adverse events and no life-threatening events being reported.

Evidence Rating Level: 1 (Excellent)  

Study Rundown: Bronchiolitis is the leading cause of hospitalization for children under the age of 2 years and a significant contributor to emergency department and clinic visits. The primary therapy in most cases is supportive care, including the use of HS. This meta-analysis showed a statistically significant reduction in the risk of admission and inpatient LOS with the use of 3% saline in bronchiolitis. The use of HS in the inpatient setting was also associated with an improvement in clinical scores for illness severity. In addition, the use of HS appeared to be safe, with few adverse events being reported. While the study included a large cohort of patients, there was significant heterogeneity between the trials; furthermore, the included trials with high risk of selection bias showed significant effects on LOS and admission rates, whereas trials with lower risk of selection bias did not. Overall, these findings suggest that HS is appropriate and safe in the treatment of bronchiolitis, but its benefit may not be as large as previously believed.

Click to read the study, published today in Pediatrics

Relevant Reading: Nebulised hypertonic saline solution for acute bronchiolitis in infants.

RELATED REPORTS

Shionogi and UBE: Novel Antiviral Drug Demonstrates Efficacy in RSV Patients

#VisualAbstract: Ziresovir Reduces Signs and Symptoms in Hospitalized Infants with Respiratory Syncytial Virus Infection

#VisualAbstract: Nirsevimab Reduces Hospitalization for RSV Bronchiolitis

In-Depth [systematic review and meta-analysis]: This study examined 24 trials selected from PubMed, the Virtual Health Library of the Latin American and Caribbean Center on Health Sciences Information and unpublished trials from ClinicalTrials.gov, resulting in 3209 included patients. Fifteen trials, with a total of 1956 patients, were examined for LOS. They showed a significantly shorter mean LOS among infants treated with HS compared to those treated with standard-of-care or normal saline, (mean difference -0.45 days; 95% CI -8.82 to -0.08, P=0.01). Seven trials, resulting in 951 patients, were pooled for assessment of HS on the risk of hospitalization. The pooled relative risk of admission with the use of HS was 0.80 (95% CI 0.67-0.96, P=0.01).The analysis of 5 trials, including 404 inpatients, showed significant improvement in clinical severity scores when using HS compared to standard of care (mean difference on day 3 of admission = -1.44, 95% CI -1.78 to -1.11, P=0.0001). Fourteen other trials (with a total of 1557 patients) reported no significant adverse events while 7 others reported few minor, self-resolving adverse events.

Image: PD

©2015 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: bronchiolitishypertonicsaline
Previous Post

Apgar score not predictive of mortality or neurological outcome

Next Post

ACP releases practice guidelines for the evaluation of suspected acute pulmonary embolism

RelatedReports

RSV positivity associated with reduced serious bacterial infection risk [Classics Series]
Pharma

Shionogi and UBE: Novel Antiviral Drug Demonstrates Efficacy in RSV Patients

February 24, 2025
#VisualAbstract: Ziresovir Reduces Signs and Symptoms in Hospitalized Infants with Respiratory Syncytial Virus Infection
StudyGraphics

#VisualAbstract: Ziresovir Reduces Signs and Symptoms in Hospitalized Infants with Respiratory Syncytial Virus Infection

October 7, 2024
#VisualAbstract: Nirsevimab Reduces Hospitalization for RSV Bronchiolitis
StudyGraphics

#VisualAbstract: Nirsevimab Reduces Hospitalization for RSV Bronchiolitis

July 22, 2024
High error rate among parents measuring liquid medications
Infectious Disease

Respiratory syncytial virus disproportionately affects pre-term infants over term infants

April 25, 2024
Next Post
ACP releases practice guidelines for the evaluation of suspected acute pulmonary embolism

ACP releases practice guidelines for the evaluation of suspected acute pulmonary embolism

Cervical cancer screening practices less cost-effective than suggested guidelines

Cervical cancer screening practices less cost-effective than suggested guidelines

Unmet healthcare need in adolescence linked to poor adult outcomes

2 Minute Medicine Rewind September 20 – September 27, 2015

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Structured exercise intervention improves survival in colon cancer patients
  • #VisualAbstract: Neoadjuvant and Adjuvant Pembrolizumab in Locally Advanced Head and Neck Cancer
  • Cerebral embolic protection does not decrease stroke incidence in TAVI patients
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
No Result
View All Result

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.